201150-74-5Relevant academic research and scientific papers
Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides
Chan, Wai N.,Hadley, Michael S.,Harling, John D.,Herdon, Hugh J.,Orlek, Barry S.,Riley, Graham J.,Stead, Rachel E. A.,Stean, Tania O.,Thompson, Mervyn,Upton, Neil,Ward, Robert W.
, p. 2085 - 2094 (2000)
SAR studies around a series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides, identified by high-throughput screening at the novel SB-204269 binding site, have provided compounds such as 13, 29-33 with high affinity and excellent anticonvulsant activity in animal models. Copyright (C) 2000 Elsevier Science Ltd.
