201151-04-4Relevant academic research and scientific papers
Ring-closing metathesis/fragmentation route to geometrically defined medium-ring cycloalkenes: Total synthesis of (±)-periplanone C
Ivkovic, Aleksandar,Matovic, Radomir,Saicic, Radomir N.
, p. 1221 - 1224 (2004)
The combination of alkene metathesis and β-fragmentation offers an efficient entry into (Z)-configured medium-ring cycloalkenes. The versatility of this method is demonstrated by the total synthesis of Periplanone C, a semiochemical of Periplaneta america
Ring closing metathesis/fragmentation route to (Z)-configured medium ring cycloalkenes. Total synthesis of (±)-periplanone C
Matovic, Radomir,Ivkovic, Aleksandar,Manojlovic, Marija,Tokic-Vujosevic, Zorana,Saicic, Radomir N.
, p. 9411 - 9419 (2007/10/03)
(Chemical Equation Presented) The combination of ring closing metathesis and β-fragmentation offers an efficient entry into (Z)-configured medium ring cycloalkenes. The fragmentation step can be effected under anionic or radical conditions. The versatilit
NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF
-
Page 123, (2010/02/07)
A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.
