201155-13-7Relevant academic research and scientific papers
REMEDIES FOR ISCHEMIC DISEASES
-
, (2008/06/13)
A medicament for ischemic diseases, which comprises as its active ingredient an oxygen-containing heterocyclic derivative represented by the following general formula (I): wherein R1represents (wherein R4represents an alkyl group, an
OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES
-
, (2008/06/13)
An oxygen-containing heterocyclic derivative represented by the following formula (I) and its salt, and a solvate and a hydrate thereof: wherein: R1:hydrogen atom, R8-CO-, R8-O-CO-or other wherein R8 represents C1-C20 alkyl, aryl or other,R2, R4 and, R6 :a hydrogen atom, C1-C5 alkyl or other,R3 and R5 :a hydrogen atom, C1-C20 alkyl or other,R7:a hydrogen atom, R9-CO-or other wherein R9 represents C1-C10 alkyl group or other,A:C1-C3 alkylene groupn:0 or 1.The oxygen-containing heterocyclic derivatives of the present invention have potent inhibitory activity against cysteine proteases and are excellent in oral absorbability, tissue distribution, and cellular membrane permeability. Therefore, they are useful as therapeutic medicament for diseases such as cerebral apoplexy, Alzheimer's disease and the like.
