201155-19-3

Upstream product

• 167766-55-4 N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide 

Downstream Products

• 853208-68-1 N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-methoxytetrahydrofuran-3-yl]-L-leucinamide 
• 934812-98-3 (3S)-3-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)tetrahydrofuran-2-yl acetate 

Relevant academic research and scientific papers

COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT

The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said c

AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT

The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.

Novel derivatives of 2-hydroxytetrahydrofuran and their use as medicaments

The invention relates to derivatives of 2-hydroxytetrahydrofuran corresponding to general formula (I) in which A represents the radical, in which R1, R2, R4, R5 and R6 represent (in particular), independently, H, a halogen atom, OH, alkyl or alkoxy, R3 represents H, alkyl or —COR10, R10 representing H, alkyl or alkoxy, and W represents a bond, —CH2—CH2—, —CH═CH—, —O—, —S— or —NR11— in which R11 represents H or alkyl; X represents —CO—, —Y—CO—, —O—Y—CO— or —NR12—Y—CO—, Y represents an alkylene or haloalkylene alkyl, R12 represents H, alkyl or —COR13, R13 represents H, alkyl, haloalkyl or alkoxy, AA represents, each time that it occurs, a natural or non-natural amino acid; n represents 2 or 3; and finally R represents H, alkyl or —CO—R19, R19 representing alkyl. These compounds have a calpain inhibiting activity and/or an activity which traps the reactive oxygen species and can be used for preparing a medicament intended to treat the inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, cachexia, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.

REMEDIES FOR ISCHEMIC DISEASES

A medicament for ischemic diseases, which comprises as its active ingredient an oxygen-containing heterocyclic derivative represented by the following general formula (I): wherein R1represents (wherein R4represents an alkyl group, an

OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES

An oxygen-containing heterocyclic derivative represented by the following formula (I) and its salt, and a solvate and a hydrate thereof: wherein: R1:hydrogen atom, R8-CO-, R8-O-CO-or other wherein R8 represents C1-C20 alkyl, aryl or other,R2, R4 and, R6 :a hydrogen atom, C1-C5 alkyl or other,R3 and R5 :a hydrogen atom, C1-C20 alkyl or other,R7:a hydrogen atom, R9-CO-or other wherein R9 represents C1-C10 alkyl group or other,A:C1-C3 alkylene groupn:0 or 1.The oxygen-containing heterocyclic derivatives of the present invention have potent inhibitory activity against cysteine proteases and are excellent in oral absorbability, tissue distribution, and cellular membrane permeability. Therefore, they are useful as therapeutic medicament for diseases such as cerebral apoplexy, Alzheimer's disease and the like.