167766-55-4

Upstream product

• 2018-66-8 Z-Leu-OH 
• 6305-38-0 (S)-(-)-α-amino-γ-butyrolactone hydrobromide 

Downstream Products

• 167765-43-7 (2S,3S)-2-acetoxy-3-((S)-2-benzyloxycarbonylamino-4-methylvalerylamino)tetrahydrofuran 
• 201155-19-3 N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-hydroxytetrahydrofuran-3-yl]-L-leucinamide 

Relevant academic research and scientific papers

AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT

The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.

COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT

The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said c

Novel derivatives of 2-hydroxytetrahydrofuran and their use as medicaments

The invention relates to derivatives of 2-hydroxytetrahydrofuran corresponding to general formula (I) in which A represents the radical, in which R1, R2, R4, R5 and R6 represent (in particular), independently, H, a halogen atom, OH, alkyl or alkoxy, R3 represents H, alkyl or —COR10, R10 representing H, alkyl or alkoxy, and W represents a bond, —CH2—CH2—, —CH═CH—, —O—, —S— or —NR11— in which R11 represents H or alkyl; X represents —CO—, —Y—CO—, —O—Y—CO— or —NR12—Y—CO—, Y represents an alkylene or haloalkylene alkyl, R12 represents H, alkyl or —COR13, R13 represents H, alkyl, haloalkyl or alkoxy, AA represents, each time that it occurs, a natural or non-natural amino acid; n represents 2 or 3; and finally R represents H, alkyl or —CO—R19, R19 representing alkyl. These compounds have a calpain inhibiting activity and/or an activity which traps the reactive oxygen species and can be used for preparing a medicament intended to treat the inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, cachexia, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.