20120-02-9

Basic information

• Product Name: (S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one
• CAS NO: 20120-02-9
• Molecular Weight: 290.446
• Mol File: 20120-02-9.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one(20120-02-9)
• EPA Substance Registry System: (S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one(20120-02-9)

Safety Data

• Hazardous Substances Data: 20120-02-9(Hazardous Substances Data)

Upstream product

• 571-20-0 (5α)-androstane-3β,17β-diol 
• 57711-44-1 Androsterone-dimethyl-tert.-butylsilyl-ether 
• 1192475-82-3 androstendione 
• 19325-01-0 C₂₁H₃₄OS₂ 
• 571-20-0 (3S,5S,10S,13S)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol 

Downstream Products

• 846-46-8 androstanedione 
• 571-20-0 (5α)-androstane-3β,17β-diol 
• 2061-71-4 3α-hydroxy-17a-oxa-D-homo-5α-androstan-17-one 

Relevant articles and documents

Heterogeneous Catalysis in Carbonyl Regeneration from 1,3-Dithiolanes and 1,3-Dithianes by Zirconium Sulfophenyl Phosphonate

Layered zirconium sulfophenyl phosphonate was found to be an efficient heterogeneous catalyst for mild hydrolysis of 1,2 dithiolanes and 1,3 dithianes to their corresponding carbonyl compounds.

Catalytic removal of tert-butyldimethylsilyl (TBS) ether by PVP-I

A mild, efficient and rapid protocol the deprotection of alcoholic TBDMS ethers using PVP-1 as catalyst in methanol, the procedure of deprotection of various TBDMS ethers were found to be very convenient, easy work-up, high yielding.

Stereo selective one-step reduction in the steroid skeleton 4 - ene -3 - ketone as a 3 α - hydroxy - 5 β - hydrogen A/B cis structure method

The invention relates to a method for one-step reduction of a 4-ene-3-one structure in a steroid skeleton into an A/B cis-3a-hydroxy-5b-hydrogen structure, belonging to the fields of organic chemistry and drug synthesis. According to the method, under the conditions of room temperature and an environment of absolute ethyl alcohol, cuprous chloride is used as a catalyst and sodium borohydride is used as a reducing agent for high-selectivity conversion of the 4-ene-3-one structure of 4-AD, ADD and derivatives thereof into the A/B cis-3a-hydroxy-5b-hydrogen structure. According to results of X-diffraction results, an androstane-3a-hydroxy-5b-hydrogen-17-one product prepared by using the method has a stereo structure; reaction conditions are mild and simple; used reagents are cheap and easily available; operation is convenient; good repeatability is realized, and high yield is obtained. The method provided by the invention lays a good foundation for exploitation of resourceful utilization of sterol and for research on synthesis of drugs like ursodesoxycholic acid, chenodeoxycholic acid, deoxycholic acid and ecdyson with the A/B cis-structure with non-cholic acid type steroids as raw materials.

A New Procedure for Dethioacetalization via Equilibrium Exchange with Aqueous Acetone, Paraformaldehyde and Amberlyst 15 as Acidic Catalyst

Carbonyl compounds were regenerated from corresponding Ethanediyl S,S-Acetals via equilibrium exchange with aqueous acetone, paraformaldehyde and Amberlyst 15, as acidic catalyst, at 80 deg C.

CHEMOSELECTIVITY IN MOLYBDENUM CATALYZED ALCOHOL AND ALDEHYDE OXIDATIONS

Hydrogen peroxide in the presence of (NH4)6Mo7O24*4H2O and potassium carbonate is a chemoselective method to oxidize secondary alcohols to ketones and to oxidize aldehydes to acids, the latter also accelerated by cerium chloride.

Synthesis of new steroid haptens for radioimmunoassay. III. 15beta Carboxyethylmercaptosteroid bovine serum albumin conjugates. Specific antisera for radioimmunoassay.

The synthesis of 15β carboxyethylmercapto 5α dihydrotestosterone, 15β carboxyethylmercapto 5α androstane 3β, 17β diol and 15β carboxyethylmercapto 5α androstane 3α, 17β diol and the preparation of their bovine serum albumin (BSA) conjugates are described.