201210-78-8

Basic information

• Product Name: N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester
• Synonyms: N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester
• CAS NO: 201210-78-8
• Molecular Weight: 335.292
• Mol File: 201210-78-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester(201210-78-8)
• EPA Substance Registry System: N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester(201210-78-8)

Safety Data

• Hazardous Substances Data: 201210-78-8(Hazardous Substances Data)

Upstream product

• 201210-70-0 succinic acid benzyl ester (5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl ester 
• 201210-72-2 succinic acid mono[(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl] ester 

Downstream Products

• 50-00-0 formaldehyd 
• 51-21-8 5-fluorouracil 
• 102-14-7 N-phenyl-succinamic acid 

Relevant articles and documents

Synthesis and reactivity of 5-fluorouracil/cytarabine mutual prodrugs

Two mutual prodrugs, in which two different anti-cancer drugs are attached to the same molecule via labile linkages, are synthesized and examined kinetically. One of the mutual prodrugs loses a drug component under physiological conditions within an hour, but the other mutual prodrug (having a longer spacer between the two drugs) is stable to chemical degradation even at hither pH values. Thus, enzymatic hydrolysis alone will release the two anti-cancer drugs. The potential value of anti-cancer mutual prodrugs is discussed.