201211-24-7Relevant academic research and scientific papers
Adenosine deaminase inhibitors: Synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R-nonyl)adenine [(+)-EHNA]
Pragnacharyulu,Varkhedkar,Curtis,Chang,Abushanab
, p. 4694 - 4700 (2007/10/03)
The synthesis and biological evaluation of three classes of chain-modified derivatives of (+)-EHNA are described. Among the 5',6'-unsaturated derivatives, the Z-isomer was the most potent inhibitor of adenosine deaminase (ADA) but 3-fold less active than
Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS)
Curtis, Mark A.,Varkhedkar, Vaibhav,Pragnacharyulu, Palle V. P.,Abushanab, Elie
, p. 1639 - 1642 (2007/10/03)
Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity.
