201211-60-1

Upstream product

• 191277-08-4 4-({(4-tert-Butoxycarbonylamino-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-benzoic acid methyl ester 

Downstream Products

• 191277-10-8 4-({(4-tert-Butoxycarbonylamino-butyl)-[3-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]-carbamoyloxy}-methyl)-benzoic acid 

Relevant academic research and scientific papers

Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase

A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fmoc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N1, N6-bis(glurathionyl)spermidine [trypanothione], and a range of related analogues were prepared for biological evaluation as previously communicated.