201230-92-4

Upstream product

• 174003-96-4 (2R,1'S,2'S)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether 
• 128373-64-8 (2S,3E)-1,2-isopropylidene-5-O-benzyl-3-pentene-1,2,5-triol 
• 158724-99-3 (S)-4-((1S,3S)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2,2-dimethyl-[1,3]dioxolane 
• 174003-93-1 (S)-1-((1S,3S)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol 

Relevant academic research and scientific papers

A highly diastereoselective synthesis of trans-3,4-(difluoromethano)glutamic acid

Reaction of enantiomerically pure N-(4'-bromo-4',4'-difluorocrotonoyl)oxazolidinone 5 with lithium enolate of N-diphenylmethylideneglycinate 6 in DMF proceeded in highly diastereoselective manner to give trans-disubstituted gem-difluorocyclopropane 7, which was readily converted to the 3,4-(difluoromethano)glutamic acid 4.