158724-99-3

Upstream product

• 2154-59-8 difluoro-methylene 
• 128373-64-8 (2S,3E)-1,2-isopropylidene-5-O-benzyl-3-pentene-1,2,5-triol 
• 1895-39-2 sodium chlorodifluoroacetate 

Downstream Products

• 174003-93-1 (S)-1-((1S,3S)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol 
• 201230-92-4 (R)-2-Azido-2-((1S,3S)-3-benzyloxymethyl-2,2-difluoro-cyclopropyl)-ethanol 
• 201230-95-7 (1S,3S)-3-((R)-Benzyloxycarbonyl-tert-butoxycarbonylamino-methyl)-2,2-difluoro-cyclopropanecarboxylic acid benzyl ester 
• 201230-94-6 (R)-((1S,3S)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-tert-butoxycarbonylamino-acetic acid methyl ester 
• 201230-93-5 [(R)-1-((1S,3S)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 174003-96-4 (2R,1'S,2'S)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS OF DIFLUOROCYCLOPROPANES

A highly diastereoselective synthesis of functionalized trans gem-difluorocyclopropane carboxylate 3 was achieved through sequential Michael addition of lithium enolate of homochiral N-acylimidazolidinone 2 with 2,4,6-trimethylphenyl (TMP) 4-bromo-4,4-dif

Preparation of difluoro analogs of CCGs and their pharmacological evaluations

All the stereoisomers of 2-(2-carboxy-3,3-difluorocyclopropyl)glycines (F2CCGs) were synthesized in enantiomerically pure forms using (R)-2,3-O- isopropyl-ideneglyceraldehyde as a chiral precursor. L-F2CCG-I, one of the stereoisomers

A highly diastereoselective synthesis of trans-3,4-(difluoromethano)glutamic acid

Reaction of enantiomerically pure N-(4'-bromo-4',4'-difluorocrotonoyl)oxazolidinone 5 with lithium enolate of N-diphenylmethylideneglycinate 6 in DMF proceeded in highly diastereoselective manner to give trans-disubstituted gem-difluorocyclopropane 7, which was readily converted to the 3,4-(difluoromethano)glutamic acid 4.