20126-55-0

Upstream product

• 64826-51-3 phenyl 1-oxo-pyridin-2-yl disulfide 
• 107-03-9 1-thiopropane 
• 16079-15-5 phenylsulfanylium 
• 108-98-5 thiophenol 
• 150-60-7 dibenzyl disulphide 
• 136852-78-3 2-n-propyldithiopyridine-N-oxide 

Downstream Products

• 1193-82-4 (S)-methylphenylsulfoxide 
• 4850-71-9 (R)-methyl phenyl sulfoxide 
• 882-33-7 diphenyldisulfane 

Relevant academic research and scientific papers

Directed oxidative coupling of thiols in the synthesis of unsymmetrical disulfides

Oxidative coupling of two different thiols bearing aliphatic, alicyclic, aromatic, and hetero-aromatic moieties promoted by mild oxidizing agents, viz., sterically hindered o-benzo(imino)-quinones, carried out in N-methylpyrrolidone at room temperature led to unsymmetrical disulfides. Among the studied oxidizers, the most active was 3,6-di-tert-butyl-o-benzoquinone, which, in contrast to 3,5-di-tert-butyl-o-benzoquinone, was not involved in the Michael addition. Under the optimal reaction conditions, the yields of the target unsymmetrical disulfides reach 81%.

A new electrochemical method of preparation of unsymmetrical disulfides

A new method is described for the preparation of unsymmetrical disulfides by reaction of the electrogenerated sulfenium cation R1-S+ with thiols or disulfides.

Synthesis of Disulfides via Sulfenylation of Alkyl and Aryldithiopyridine N-Oxides

Alkyl and aryldithiopyridine N-oxides were prepared by reaction of 2,2'-dithiopyridine-1,1'-dioxide with various thiols in high yields.Some of the mixed disulfide products could in turn be used to sulfenylate efficiently other thiols.Therefore, practical and efficient synthetic methods for both symmetrical and unsymmetrical disulfides were developed.