201287-50-5Relevant academic research and scientific papers
2-substituted-4-methoxybenzimidazole-based PDE4 inhibitors
Regan, John,Bruno, Joseph,McGarry, Daniel,Poli, Gregory,Hanney, Barbara,Bower, Shelly,Travis, Jeffrey,Sweeney, Dennis,Miller, Bruce,Souness, John,Djuric, Stevan
, p. 2737 - 2742 (1998)
A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.
Substituted azabicyclic compounds
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, (2008/06/13)
This invention is directed to certain physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
