2-substituted-4-methoxybenzimidazole-based PDE4 inhibitors

DOI: 10.1016/S0960-894X(98)00497-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2737 - 2742 (1998)

Update date:2022-07-29

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Authors:

Regan, John

Bruno, Joseph

McGarry, Daniel

Poli, Gregory

Hanney, Barbara

Bower, Shelly

Travis, Jeffrey

Sweeney, Dennis

Miller, Bruce

Souness, John

Djuric, Stevan

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Article abstract of DOI:10.1016/S0960-894X(98)00497-1

A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.

Full text of DOI:10.1016/S0960-894X(98)00497-1

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Product name:methyl 3-(1-imino-3-phenylpropylamino)-4-methoxybenzoate

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