2-substituted-4-methoxybenzimidazole-based PDE4 inhibitors

DOI: 10.1016/S0960-894X(98)00497-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2737 - 2742 (1998)

Update date:2022-07-29

Topics:

Authors:

Regan, John

Bruno, Joseph

McGarry, Daniel

Poli, Gregory

Hanney, Barbara

Bower, Shelly

Travis, Jeffrey

Sweeney, Dennis

Miller, Bruce

Souness, John

Djuric, Stevan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00497-1

A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.

Full text of DOI:10.1016/S0960-894X(98)00497-1

Products guided by the article

Product name:methyl 3-(1-imino-3-phenylpropylamino)-4-methoxybenzoate

Cas No:201287-50-5

R&D Labs maybe for 201287-50-5

ChengduChroma-BiotechCo.,Ltd.

Contact:86-28-61993785

Address:No.70-13-21, North Section, Erhuan
Jiangyin Tenghua Import&Export Co.,Ltd.

Contact:+86-510-86263875

Address:Room 402-B,9 Yanling Road, Jiangyin,Jiangsu, China
Morni Chemical Co.,Ltd(expird)

Contact:07972538150

Address:Zhongshan Road Street No.4
shanghai payne pharm co.,ltd.

Contact:+86-021-58123769

Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
Watson International Ltd

Contact:+44 (0)2036089360-31

Address:Chanceryhouse,Chancery Lan

Relevant to this article

Kinetics and mechanistic investigation into the possible activation of imidazolium trans-[tetrachloridodimethylsulfoxideimidazoleruthenate(iii)], NAMI-A, by 2-mercaptoethane sulfonate

Doi:10.1039/c4dt01643b
(2014)
1,2,3,5,7-pentaselena-4,6,8-triphosphocane as the revised structure for "3,4,5-triselenoxo-1,2-diselena-3,4,5-triphospholane" determined by X-ray analysis

Doi:10.1246/cl.1998.17
(1998)
Hydrazone exchange: a viable route for the solid-tethered synthesis of [2]rotaxanes

Doi:10.1039/d1nj00388g
(2021)
Rotational features of carbon-nitrogen bonds in axially chiral o-tert- butyl anilides and related molecules. Potential substrates for the 'prochiral auxiliary' approach to asymmetric synthesis

Doi:10.1016/S0957-4166(97)00599-5
(1997)
Mechanistic information of substitution reaction of W(PhC≡CPh)₃(CO) with trimethylphosphine

Doi:10.1016/S0022-328X(97)00418-X
(1997)
Complexes of strong bidentate Lewis acids derived from 2,2′-(1,3-butadiyne-1,4-diyl)bis[phenol]

Doi:10.1021/om970901p
(1998)

Article Doi