201287-86-7Relevant academic research and scientific papers
Unnatural β-L-enantiomers of nucleoside analogues as potent anti- hepatitis B virus agents
Gosselin,Boudou,Griffon,Pavia,Pierra,Imbach,Faraj,Sommadossi
, p. 1731 - 1738 (1998)
Several 2'- or 3'- substituted 2',3'-dideoxy-β-L-nucleosides bearing adenine as the base were stereospecifically synthesized and their antiviral properties examined. Two of them, namely 2'-azido- and 3'-azido-2',3'- dideoxy-β-L-adenosine (2'-N3
New unnatural L-nucleoside enantiomers: From their stereospecific synthesis to their biological activities
Gosselin,Boudou,Griffon,Pavia,Pierra,Imbach,Aubertin,Schinazi,Faraj,Sommadossi
, p. 1389 - 1398 (2007/10/03)
Several purine and pyrimidine β-L-dideoxynucleosides were stereospecifically synthesized and their antiviral properties examined. Two of them, namely β-L-2',3'-dideoxyadenosine (β-L-ddA) and its 2',3'- didehydro derivative (β-L-d4A) were found to have significant anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HSV) activities in cell culture.
Anti-human immunodeficiency and anti-hepatitis B virus activities of β-L-2',3'-dideoxy purine nucleosides
Bolon, Pascal J.,Wang, Peiyuan,Chu, Chung K.,Gosselin, Gilles,Boudou, Valerie,Pierra, Claire,Mathe, Christophe,Imbach, Jean-Louis,Faraj, Abdesselem,El Alaoui, M. Abdelaziz,Sommadossi, Jean-Pierre,Balakrishna Pai,Zhu, Yong-Lian,Lin, Ju-Sheng,Cheng, Yung-Chi,Schinazi, Raymond F.
, p. 1657 - 1662 (2007/10/03)
β-L-2',3'-Dideoxyadenosine, β-L-2',3'-didehydro-2',3'-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that β-L-2',3'-didehydro-2',3'-dideoxyadenosine (7) exhibited significant anti-HIV (EC50 0.38 μM in PBM cells) and anti-HBV activity (EC50 1.2 μM).
