201289-58-9Relevant academic research and scientific papers
Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties
Fuji, Kaoru,Watanabe, Yukari,Ohtsubo, Tadamune,Nuruzzaman, Mohammad,Hamajima, Yoshio,Kohno, Michiaki
, p. 1334 - 1337 (2007/10/03)
Straight chain compounds having a phenylisoserine unit and an oxetane ring at the α- and ω- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.
Total syntheses of macrocyclic marine alkaloids, haliclamines A and B: A convenient and expeditious assembly of 3-substituted pyridine derivatives with different alkyl chains to the bispyridinium macrocycle
Morimoto, Yoshiki,Yokoe, Chiho,Kurihara, Hajime,Kinoshita, Takamasa
, p. 12197 - 12214 (2007/10/03)
The total syntheses of haliclamines A (1) and B (2), macrocyclic marine alkaloids closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, have efficiently been achieved via stepwise controlled inter- and intramolecular N-alkylations of 3- alkylpyridine derivatives such as 40 and 41. The general synthetic methodology toward the bispyridinium macrocycle 44, a key biogenetic equivalent of the polycyclic marine alkaloids, has been proposed through the total syntheses.
Total synthesis of haliclamine A, a macrocyclic marine alkaloid related to the key biogenetic intermediate of manzamines
Morimoto, Yoshiki,Yokoe, Chiho
, p. 8981 - 8984 (2007/10/03)
The first total synthesis of haliclamine A (1), a macrocyclic marine alkaloid closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, has been efficiently achieved via stepwise inter- and intramolecular N-alkylations of 3-alkylpyridine derivatives 26 and 28.
