201335-92-4 Usage
Uses
Used in Peptide Synthesis:
FMOC-D-TYR(PO3ME2)-OH serves as a crucial component in peptide synthesis, where it is utilized as an amino acid building block. The FMOC group's role in protecting the N-terminus ensures that the tyrosine residue can be selectively incorporated into growing peptide chains without unwanted side reactions, thus enhancing the yield and purity of the synthesized peptides.
Used in Pharmaceutical Research:
In the pharmaceutical industry, FMOC-D-TYR(PO3ME2)-OH is employed as a research tool for investigating the mechanisms of protein interactions and cellular signaling. The phosphorylated tyrosine residue is a common post-translational modification that can modulate protein function, making FMOC-D-TYR(PO3ME2)-OH instrumental in the development of drugs targeting specific signaling pathways.
Used in Biochemical Education:
FMOC-D-TYR(PO3ME2)-OH also finds application in educational settings, where it can be used to demonstrate the principles of peptide synthesis and the impact of post-translational modifications on protein function. This makes it a valuable teaching aid for students learning about the intricacies of biochemistry and molecular biology.
Overall, FMOC-D-TYR(PO3ME2)-OH is a multifaceted chemical entity with applications spanning from controlled peptide synthesis to the elucidation of complex biological processes, highlighting its significance in both research and educational contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 201335-92-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,3,3 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 201335-92:
(8*2)+(7*0)+(6*1)+(5*3)+(4*3)+(3*5)+(2*9)+(1*2)=84
84 % 10 = 4
So 201335-92-4 is a valid CAS Registry Number.
201335-92-4Relevant academic research and scientific papers
Alternative Strategies for the Fmoc Solid-Phase Synthesis of O4-Phospho-L-tyrosine-Containing Peptides
Kitas, Eric A.,Knorr, Reinhard,Trzeciak, Arnold,Bannwarth, Willi
, p. 1314 - 1328 (2007/10/02)
A number of biologically relevant O4-phospho-L-tyrosine-containing peptides have been synthesized by either the global phosphorylation of the side-chain-unprotected L-tyrosine moiety in presynthesized resin-bound peptides or alternatively by the incorporation of suitable protected O4-phospho-L-tyrosine building blocks in the continuous-flow method of Fmoc solid-phase peptide synthesis.Different phosphate-protecting groups have been applied.
Fmoc-polyamide solid phase synthesis of an O-phosphotyrosine-containing tridecapeptide
Kitas,Perich,Wade,Johns,Tregear
, p. 6229 - 6232 (2007/10/02)
The incorporation of O-phosphotyrosine into synthetic peptides using Fmoc-Tyr(PO3Me2)-OH in the Fmoc-polyamide procedure is described with the preparation of the model PTyr-tridecapeptide sequence H-Arg-Leu-Ile-Glu-Asp-Asn-Glu-PTyr-T
