201413-00-5Relevant academic research and scientific papers
Tailored Palladium Catalysts for Selective Synthesis of Conjugated Enynes by Monocarbonylation of 1,3-Diynes
Beller, Matthias,Franke, Robert,Jackstell, Ralf,Liu, Jiawang,Schneider, Carolin,Yang, Ji
, p. 9032 - 9040 (2020)
For the first time, the monoalkoxycarbonylation of easily available 1,3-diynes to give synthetically useful conjugated enynes has been realized. Key to success was the design and utilization of the new ligand 2,2′-bis(tert-butyl(pyridin-2-yl)phosphanyl)-1,1′-binaphthalene (Neolephos), which permits the palladium-catalyzed selective carbonylation under mild conditions, providing a general preparation of functionalized 1,3-enynes in good-to-high yields with excellent chemoselectivities. Synthetic applications that showcase the possibilities of this novel methodology include an efficient one-pot synthesis of 4-aryl-4H-pyrans as well as the rapid construction of various heterocyclic, bicyclic, and polycyclic compounds.
Stereoselective dabco-catalyzed synthesis of (E)-α-Ethynyl-α, β-unsaturated esters from allenyl acetates
Choe, Yongsik,Lee, Phil Ho
supporting information; experimental part, p. 1445 - 1448 (2009/09/06)
(E)-α-Ethynyl-α,β-unsaturated esters were exclusively prepared in good to excellent yields from treatment of allenyl acetates with 10 mol % DABCO in DMF at room temperature.
