53949-11-4Relevant articles and documents
An asymmetric organocatalytic vinylogous Mannich reaction of 3-methyl-5-arylfuran-2(3H)-ones with N -(2-pyridinesulfonyl) imines: Enantioselective synthesis of δ-amino γ,γ-disubstituted butenolides
Wang, Zhen-Hua,You, Yong,Chen, Yong-Zheng,Xu, Xiao-Ying,Yuan, Wei-Cheng
, p. 1636 - 1640 (2018/03/21)
An asymmetric organocatalytic vinylogous Mannich reaction of 3-methyl-5-arylfuran-2(3H)-ones with N-(2-pyridinesulfonyl)imines has been developed with 5 mol% thiourea-tertiary amine as the catalyst. A series of δ-amino γ,γ-disubstituted butenolides bearin
Stereoselective synthesis of: E -3-(arylmethylidene)-5-(alkyl/aryl)-2(3 H)-furanones by sequential hydroacyloxylation-Mizoroki-Heck reactions of iodoalkynes
Muthusamy, Gopinathan,Pansare, Sunil V.
, p. 7971 - 7983 (2018/11/21)
A modular, stereoselective synthesis of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones was developed. The methodology features regioselective addition of β-aryl acrylic acids to iodoacetylenes to furnish the Z-acyloxy iodoalkenes. A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. The approach was applied in a formal synthesis of the naturally occurring kinase inhibitor BE-23372M.
Rhodium(ii)-catalysed generation of cycloprop-1-en-1-yl ketones and their rearrangement to 5-aryl-2-siloxyfurans
Marichev, Kostiantyn O.,Wang, Yi,Carranco, Alejandra M.,Garcia, Estevan C.,Yu, Zhi-Xiang,Doyle, Michael P.
supporting information, p. 9513 - 9516 (2018/08/28)
Donor-acceptor cyclopropenes formed from enoldiazoketones undergo catalytic rearrangement to 5-aryl-2-siloxyfurans via a novel mechanism that involves a nucleophilic addition of the carbonyl oxygen to the rhodium-activated cyclopropene.
Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV
Bassetto, Marcella,Leyssen, Pieter,Neyts, Johan,Yerukhimovich, Mark M.,Frick, David N.,Brancale, Andrea
supporting information, p. 936 - 940 (2017/02/10)
A ligand-based approach was applied to screen in silico a library of commercially available compounds, with the aim to find novel inhibitors of the HCV replication starting from the study of the viral NS3 helicase. Six structures were selected for evaluat
Palladium-catalyzed carbonylative coupling of aryl iodides and benzyl acetylenes to 3-alkylidenefuran-2-ones under mild conditions and its density functional theory modeling
Wu, Xiao-Feng,Jiao, Haijun,Neumann, Helfried,Beller, Matthias
, p. 16177 - 16185 (2013/02/22)
A general and efficient method for the palladium-catalyzed carbonylative coupling of aryl iodides to benzyl acetylenes has been developed. Various furanones have been prepared in excellent yields from their corresponding benzyl acetylenes at room temperat
A general cyclocarbonylation of aryl bromides and triflates with acetylenes: Palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones
Wu, Xiao-Feng,Sundararaju, Basker,Anbarasan, Pazhamalai,Neumann, Helfried,Dixneuf, Pierre H.,Beller, Matthias
supporting information; experimental part, p. 8014 - 8017 (2011/09/14)
Making use of CO: An improved efficient synthesis of 5-aryl-3- alkylidenefuran-2-ones has been developed (see scheme). Starting from readily available (hetero)aryl bromides or aryl triflates and alkynes, furanones were produced in good yields through a do
Condensation of 4-aryl-4-oxobutanoic acids with benzylamines: Synthetic and structural studies on 1-arylmethyl-3-[(E)-1-arylmethylidene]-5-phenyl-2,3- dihydro-1H-2-pyrrolones
Surya Prakash Rao,Senthilkumar,Gopu,Rafi, Shaik
, p. 292 - 297 (2008/09/20)
The microwave-mediated reaction of 4-aryl-4-oxobutanoic acids with benzylamines furnished 1-arylmethyl-3-[(E)-1-arylmethylidene]-5-phenyl-2,3- dihydro-1H-pyrrolones. This result is in contract to the earlier report on this reaction conducted under neat conditions. Structures for the products were assigned on the basis of spectral data and confirmed by independent synthesis.
Electronic absorption spectra of arylmethylene, ethylidene, and allylidene 3H-furan-2-one derivatives
Egorova,Kamneva
, p. 1366 - 1369 (2008/03/27)
The electronic absorption spectra of 3H-furan-2-ones containing substituents with varied length of the conjugation chain in position C 3 of the heteroring are examined. The conclusions are made about the direction of the band shift depending on
Fluorophores related to the green fluorescent protein
Bourotte, Maryline,Schmitt, Martine,Follenius-Wund, Anny,Pigault, Claire,Haiech, Jacques,Bourguignon, Jean-Jacques
, p. 6343 - 6348 (2007/10/03)
Imidazolin-5-one derivatives and isosteres (oxazolinones, butenolides, and pyrrolinones) of the 4-hydroxybenzylidene-imidazolinone chromophore of the GFP have been synthesized and their photophysical properties have been investigated.
NEW COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYES AND PIGMENTS
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Page 15, (2008/06/13)
Compounds of formula (1) wherein R1 is hydrogen, hydroxy, halogen, nitro, cyano, amino, carboxy, carboxylic ester, sulfo, sulfonic ester, carboxylic amide, sulfonic amide, alkoxy, aryloxy, alkylthio or arylthio, X is -0-, -S-, -NH- or -N(alkyl)-, Y is hyd
