201420-61-3

Basic information

• Product Name: Adenosine, N,N-dibenzoyl-2'-deoxy-, 3'-benzoate
• CAS NO: 201420-61-3
• Molecular Formula: C31H25N5O6
• Molecular Weight: 563.569
• Mol File: 201420-61-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Adenosine, N,N-dibenzoyl-2'-deoxy-, 3'-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, N,N-dibenzoyl-2'-deoxy-, 3'-benzoate(201420-61-3)
• EPA Substance Registry System: Adenosine, N,N-dibenzoyl-2'-deoxy-, 3'-benzoate(201420-61-3)

Safety Data

• Hazardous Substances Data: 201420-61-3(Hazardous Substances Data)

Upstream product

• 51549-30-5 5'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 1031809-78-5 O^5'-tert-butyldimethylsilyl-N⁶,N⁶,O^3'-tribenzoyl-2'-deoxyadenosine 
• 98-88-4 benzoyl chloride 
• 958-09-8 2'-deoxy-D-adenosine 

Downstream Products

• 1259874-87-7 C₃₆H₃₄N₅O₁₁P 
• 916154-26-2 O₃',N₆,N₆-tribenzoyl-5'-oxo-2'-deoxyadenosine 
• 916154-28-4 O₃',N₆,N₆-tribenzoyl-5',5'-dihydroxy-2'-deoxyadenosine 
• 201420-63-5 Benzoic acid (2R,3S,5R)-5-(6-dibenzoylamino-purin-9-yl)-2-hydroxymethyl-2-phenylselanyl-tetrahydro-furan-3-yl ester 
• 201420-83-9 C₅₂H₄₆⁽²⁾HN₅O₆Si 
• 201420-72-6 N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide 
• 201420-65-7 Benzoic acid (2R,3S,5R)-5-(6-dibenzoylamino-purin-9-yl)-2-(diphenyl-vinyl-silanyloxymethyl)-2-phenylselanyl-tetrahydro-furan-3-yl ester 
• 201420-69-1 N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-5-phenylselanyl-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 201420-71-5 (2S,3S,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(1-hydroxy-ethyl)-tetrahydro-furan-3-ol 
• 201420-68-0 N-[9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-5-phenylselanyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 
• 201420-70-4 N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 201420-62-4 Benzoic acid (3S,5R)-5-(6-dibenzoylamino-purin-9-yl)-2-formyl-2-phenylselanyl-tetrahydro-furan-3-yl ester 

Relevant articles and documents

Design and synthesis of α-carboxy phosphononucleosides

Rhodium catalyzed O-H insertion reactions employing α- diazophosphonate 20 with appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives leads to novel 5′-phosphononucleoside derivatives. Deprotection led to a novel series of phosphono derivatives bearing a carboxylic acid moiety adjacent to the phosphonate group with potential antiviral and/or anticancer activity. The phosphononucleosides bearing an α-carboxylic acid group are envisaged as potential diphosphate mimics. Conversion to mono- and diphosphorylated phosphononucleosides has been effected for evaluation as nucleoside triphosphate mimics. Most of the novel phosphononucleosides proved to be inactive against a variety of DNA and RNA viruses. Only the phosphono AZT derivatives 56-59 showed weak activity against HIV-1 and HIV-2.

Novel synthetic approach to multibenzoylated nucleosides

An improved and highly efficient synthetic approach to multibenzoylated nucleosides bearing free 5'-hydroxyl groups is described here. By employing t-butyldimethylsilyl (TBDMS) rather than the more commonly used dimethoxytrityl (DMTr) as a temporary 5'-OH