201423-59-8

Usage

Uses

Used in Pharmaceutical Industry:
Pravastatin 6'-Ketone Sodium Salt is used as a drug for lowering cholesterol and preventing cardiovascular disease. It functions by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol synthesis, thereby reducing the levels of low-density lipoprotein (LDL) cholesterol or "bad" cholesterol in the blood. This helps in maintaining healthy cholesterol levels and reducing the risk of heart disease and stroke.

Relevant academic research and scientific papers

Metabolism of pravastatin sodium by 3α-hydroxysteroid dehydrogenase

When incubated with isolated rat hepatocytes, pravastatin sodium (PS) yielded a small amount of a metabolite in addition to two major metabolites that have already been reported. The previously uncharacterized metabolite was found to be formed by at first being enzymatically dehydrogenated to 6'- keto intermediate (R-104), followed by decomposition to give the aromatized metabolite (R-195), through spontaneous deesterification with accompanying aromatization. The PS-6'β-hydroxydehydrogenase activity was localized in cytosolic fraction and required NADP, preferentially over NAD, as a cofactor. The formation of R-195 by rat liver cytosol was strongly inhibited by indomethacin, 3α-hydroxysteroids (but not 3β-isomers) and 3-ketosteroids. The results and high substrate specificity of purified PS-6'β- hydroxydehydrogenase toward 3α-hydroxysteroids suggested that the enzyme is identical to 3α-hydroxysteroid dehydrogenase.