20143-50-4

Basic information

• Product Name: 2-(2-Oxo-2-phenylethoxy)benzonitrile
• Synonyms: 2-(2-Oxo-2-phenylethoxy)benzonitrile
• CAS NO: 20143-50-4
• Molecular Weight: 237.258
• Mol File: 20143-50-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-Oxo-2-phenylethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Oxo-2-phenylethoxy)benzonitrile(20143-50-4)
• EPA Substance Registry System: 2-(2-Oxo-2-phenylethoxy)benzonitrile(20143-50-4)

Safety Data

• Hazardous Substances Data: 20143-50-4(Hazardous Substances Data)

Upstream product

• 611-20-1 salicylonitrile 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 49615-93-2 (3-aminobenzo[b]furan-2-yl)phenylmethanone 

Relevant articles and documents

Synthesis and analgesic activity of some 1-benzofurans, 1-benzothiophenes and indoles

3-Unsubstituted 1-benzofurans 1e and 1f, 3-methyl-1-benzofurans 1a-1d, and 3-amino-1-benzofurans 2a-21, as well as 3-amino-1-benzothiophenes 3a, 3b and 3-aminoindoles 4a-4f, 11a, and 11b were prepared and tested as analgesics. The 3-amino-1-benzofurans 2 were prepared from the corresponding 2-hydroxybenzonitriles 5 and phenacyl bromides 6 via intermediates 7. Similar treatment of 2-sulfanylbenzonitrile (8) provided 3-amino-1-benzothiophenes 3. Appropriately substituted 2-aminobenzonitriles 9 then provided N-substituted 3-aminoindoles 4. 1-(Ethoxycarbonyl)indoles 4e and 4f were successfully deprotected giving indoles 11a and 11b, respectively.

Synthesis, anticonvulsant and neurotoxicity evaluation of novel n-(2-benzoylbenzofuran-3-yl)-4-(substituted) butanamides

A series of N-(2-benzoylbenzofuran-3-yl)-4-(substituted) butanamides (IVa-f) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. All the compounds was found active in MES tests. Compounds IVb, IVc, IVd and IVf were found to be potent and had activity at lower dose of 30mg/ kg in MES-test. Compounds IVa and IVe were less toxic as compared with the standard drug phenytoin.