201471-78-5Relevant academic research and scientific papers
An enantioselective total synthesis of helioporins C and e
L?lsberg, Wibke,Werle, Susen,Neud?rfl, J?rg-Martin,Schmalz, Hans-Günther
, p. 5996 - 5999 (2012)
A short and enantioselective total synthesis of helioporins C and E, which are bioactive marine diterpenes containing a serrulatane or amphilectane skeleton, was elaborated. The chirogenic step, i.e. a Cu(I)-catalyzed allylic alkylation of a cinnamyl chlo
BI- OR TETRA-GUANIDINO-BIPHENYL COMPOUNDS AS SMALL MOLECULE CARRIERS
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Page/Page column 41-42, (2008/06/13)
The invention relates to compounds of formula: I, or pharmaceutically acceptable a salts thereof, I wherein X1 X2 and X3 are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substituted with one or more substituents selected from alkyl, halo, CF3, OH, alkoxy, NH2, CN, NO2 and COOH; W is absent or is O, S or NH; Rl, R2, R3 and R4 are each independently selected from H, alkyl, aryl and a protecting group Pl; R7, R8 and R9 are each independently selected from H, alkyl, halo, CF3, OH, alkoxy, NH2, CN, NO2 and COOH; q and r are each independently 1, 2, 3 or 4; q' and r' are each independently 0, 1, 2 or 3, where q + q' and r + r' each equal 4; p is 1, 2, 3, 4 or 5, and p' is 0, 1, 2, 3 or 4, where p + p' is 5; n is 0, 1, 2, 3....6; L is (Z)mNR5R6 where Z is a hydrocarbyl group and m is 0 or 1; where R5 and R6 are each independently H, CO(CH2)jQ1 or C=S(NH)(CH2)kQ2 where j and k are each independently 0, 1, 2, 3, 4 or 5, and Q1 and Q2 are each independently selected from COOH, a chromophore or R5, R6 and the nitrogen to which they are attached together form.
A convenient procedure for the synthesis of 1-tetralone dertivatives using a Suzuki coupling-Friedel-Crafts acylation sequence
Esteban, Gemma,Lopez-Sanchez, Miguel A.,Martinez, Ma. Eugenia,Plumet, Joaquin
, p. 197 - 212 (2007/10/03)
The reported 1-tetralone derivatives have been synthesized from arylbromides using as keys steps a Suzuki coupling followed by intramolecular Friedel-Crafts acylation.
