201486-63-7Relevant academic research and scientific papers
Reactions of Weinreb amides: formation of aldehydes by Wittig reactions
Hisler, Kevin,Tripoli, Regis,Murphy, John A.
, p. 6293 - 6295 (2006)
Aldehydes are prepared in excellent yield by Wittig reactions of phosphoranes on the Weinreb amide of formic acid followed by in situ hydrolysis.
Reduction of ethanethiol esters to aldehydes
Tokuyama, Hidetoshi,Yokoshima, Satoshi,Lin, Shao-Cheng,Li, Leping,Fukuyama, Tohru
, p. 1121 - 1123 (2007/10/03)
Reduction of ethanethiol esters of α-amino acids to α-amino aldehydes by triethylsilane and catalytic palladium-on-carbon is described. α-Amino aldehydes with Boc, Cbz, or Fmoc protection could be obtained without racemization in high yield.
2-(2-aminophenyl)-acetaldehyde dimethyl acetal: A novel reagent for the protection of carboxylic acids
Arai, Eri,Tokuyama, Hidetoshi,Linsell, Martin S.,Fukuyama, Tohru
, p. 71 - 74 (2007/10/03)
The synthesis and use of 2-(2-aminophenyl)-acetaldehyde dimethyl acetal 1 are described. The amides 2, derived from this amine and carboxylic acids, are stable under basic conditions and thus can be regarded as the protected carboxylic acids. The corresponding carboxylic acids are regenerated by conversion of 2 into indolylamides 3 by treatment with CSA and subsequent hydrolysis with LiOOH or NaOH. In addition, 3 can be easily converted to esters, amides, and aldehydes.
ASYMMETRIC TOTAL SYNTHESES OF (+)- AND (-)-PULO'UPONE
Sugahara, Tsutomu,Iwata, Takashi,Yamaoka, Miyako,Takano, Seiichi
, p. 1821 - 1824 (2007/10/02)
Asymmetric total syntheses of both enantiomers of marine mollusk metabolite pulo'upone 1 have been achieved by Evans' asymmetric Diels-Alder reaction.
