20149-84-2

Basic information

• Product Name: N1-(3,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE
• Synonyms: Acetanilide,2,3’,4’-trichloro-;ART-CHEM-BB B015626;2-CHLORO-N-(3,4-DICHLOROPHENYL)ACETAMIDE;AKOS B015626;AKOS BBS-00004057;N1-(3,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE;N-(CHLOROACETYL)-3,4-DICHLOROANILINE;2-chloro-N-(3,4-dichlorophenyl)ethanamide
• CAS NO: 20149-84-2
• Molecular Formula: C₈H₆Cl₃NO
• Molecular Weight: 238.5
• Mol File: 20149-84-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 104.5-106 °C
• Boiling Point: 393.3°Cat760mmHg
• Flash Point: 191.7°C
• Appearance: /
• Density: 1.511g/cm³
• Vapor Pressure: 2.15E-06mmHg at 25°C
• Refractive Index: 1.616
• PKA: 11.35±0.70(Predicted)
• CAS DataBase Reference: N1-(3,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-(3,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE(20149-84-2)
• EPA Substance Registry System: N1-(3,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE(20149-84-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 20149-84-2(Hazardous Substances Data)

Usage

General Description

N1-(3,4-Dichlorophenyl)-2-chloroacetamide is a chemical compound that belongs to the class of acetamide derivatives. It is a white to off-white crystalline powder that is used in the synthesis of pharmaceuticals and agrochemicals. N1-(3,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE is known to have both antibacterial and antifungal properties, making it useful in the development of new drugs for combating microbial infections. Additionally, it has been studied for its potential as a herbicide for controlling the growth of unwanted vegetation. However, it is important to handle this chemical with caution, as it may have harmful effects on human health and the environment if not used properly.

InChI:InChI=1/C8H6Cl3NO/c9-4-8(13)12-5-1-2-6(10)7(11)3-5/h1-3H,4H2,(H,12,13)

Upstream product

• 95-76-1 m,p-dichloroaniline 
• 541-88-8 Chloroacetic anhydride 

Downstream Products

• 22010-25-9 piperidino-acetic acid-(3,4-dichloro-anilide) 
• 111977-85-6 1-[(3,4-dichloro-phenylcarbamoyl)-methyl]-pyridinium; chloride 
• 333986-46-2 N-(3,4-dichlorophenyl)-2-[4-(4-fluorophenyl)piperidin-1-yl]acetamide 
• 769911-41-3 3,4-dichloro-N-{2-[4-(4-fluorobenzyl)piperidin-1-yl]ethyl}aniline 
• 1228237-34-0 C₁₈H₁₉Cl₂NO₂ 

Relevant articles and documents

COMBINATION THERAPY FOR TREATING MPS1

The application is directed to compounds of formula (I) and their salts and solvates, wherein B, R1, R2, R3, R3', R4, R4', and R5 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., MPS1, optionally in combination with α-L-iduronidase or an analog or variant thereof, e.g., laronidase.

CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives

Replacement of the 5-oxopyrrolidin-3-yl fragment in the previously reported lead structure with a 1-acetylpiperidin-4-yl group led to the discovery of a novel series of potent CCR5 antagonists. Introduction of small hydrophobic substituents on the central phenyl ring increased the binding affinity, providing low to sub-nanomolar CCR5 antagonists. The selected compound 11f showed excellent antiviral activity against CCR5-using HIV-1 replication in human peripheral blood mononuclear cells (EC50 = 0.59 nM) and an acceptable pharmacokinetic profile in dogs.