33240-95-8

Upstream product

• 20149-84-2 2-chloro-N-(3,4-dichlorophenyl)acetamide 
• 95-76-1 m,p-dichloroaniline 
• 2150-93-8 N-(3,4-dichlorophenyl)acetamide 

Downstream Products

• 15233-34-8 3,4-Dichlorophenylbiguanide 
• 13344-99-5 1-(3,4-dichloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine 
• 107527-47-9 Adipinsaeure-bis- 
• 19250-09-0 3,4-dichlorophenylthiourea 
• 24072-75-1 2-Amino-5,6-dichlorobenzothiazole 
• 90415-53-5 (3,4-dichloro-phenylhydrazono)-malonyl chloride 
• 91211-09-5 (3,4-dichloro-phenylhydrazono)-malonic acid 
• 103038-71-7 α-(3,4-dichloro-anilino)-isobutyric acid 
• 103505-36-8 α-(3,4-dichloro-anilino)-isobutyric acid amide 
• 537-21-3 chlorproguanil 
• 130573-30-7 3-(3,4-Dichloro-phenyl)-1-methyl-1-((1R,2S)-2-pyrrolidin-1-yl-cyclohexyl)-thiourea 
• 56147-28-5 N-cyano-N'-(3,4-dichloro-phenyl)-guanidine 
• 100633-88-3 (3,4-Dichloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 6590-94-9 3,4-dichlorophenyl isothiocyanate 

Relevant academic research and scientific papers

Synthesis, cytotoxic evaluation, and in silico studies of substituted N-alkylbromo-benzothiazoles

In efforts to develop a new class of anticancer agents with improved efficacy and selective action, a series of N-alkylbromo-benzothiazoles were synthesized and evaluated for in vitro cytotoxic activity against various human cancer cell lines such as lung (A-549), prostate (PC-3), leukemia (THP-1), and colon (Caco-2). They were found to be highly active against prostate (PC-3) and leukemia (THP-1) cancer cells, moderately active against colon (Caco-2) cancer cells and less active against lung (A-549) cancer cells. Of the 12 compounds, two (11d, 11j) exhibit IC50 values of ≤ 1 μM against leukemia (THP-1) cancer cell lines. Compound 11l showed significant cytotoxic activity against the PC-3 (IC50 = 0.6 μM), THP-1 (IC50 = 3 μM) and Caco-2 cell lines (IC50 = 9.9 μM), respectively. Docking study of the synthesized ligand was done on epidermal growth factor receptor using ArgusLab flexible docking, to determine their observed activity. Further QSAR investigations with stepwise multiple linear regression analysis were applied to find correlation between various physicochemical parameters and anticancer activity. The QSAR results showed that anticancer activity could be modeled with descriptors. The predictive ability of models was cross-validated by observation of the low residual activity values and adjusted coefficient of variation (radj2) obtained by leave-one-out technique.

A facile and efficient method for the selective deacylation of N-arylacetamides and 2-chloro-Narylacetamides catalyzed by SOCl2

Thionyl chloride efficiently and selectively promoted the deacylation of N-arylacetamides and 2-chloro-N-arylacetamides, under anhydrous conditions, without effecting the ester group, aminosulfonyl group, or benzyloxyamide group. This method, which has been successfully applied to a variety of substrates including different N-arylacetamides and 2-chloro-N-arylacetamides, has the attractive advantages of inexpensive reagents, satisfactory selectivity, excellent yields, short reaction time, and convenient workup. This new method can probably be used to selectively deacylate between aromatic amides and alkyl amides. Springer Science+Business Media B.V. 2011.

Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives

The invention presents a biguanide derivative or its salt expressed by a formula: STR1 (where R1 and R2 are as defined in Specification), or formula: STR2 (where A and R3 is as defined in specification). This biguanide derivative or its salt is preferably used as the effective amount of a disinfectant for humans, animals, medical appliances, etc.