2015-11-4

Upstream product

• 2173-31-1 N,N-Bis-(2-phenylmercapto-aethyl)-propionamid 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 108-98-5 thiophenol 
• 930-69-8 sodium thiophenolate 
• 5535-49-9 2-Chloroethyl phenyl sulfide 
• 3111-52-2 potassium thiophenolate 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 180464-03-3 Bis-(2-phenylsulfanyl-ethyl)-phosphoramidic acid dimethyl ester 
• 1334733-18-4 C₃₁H₂₇NO₄S₂ 
• 1497171-77-3 C₁₆H₁₉ClNPdS₂⁽¹⁺⁾*Cl^(1-) 

Relevant academic research and scientific papers

Synthesis of polydentate chalcogen-containing ligands using the system hydrazine hydrate–base

The reaction of dichlorodiethyl ether or dichlorodiethylamine hydrochloride with potassium or ethanolammonium dichalcogenides prepared in situ from elemental sulfur or selenium in the system hydrazine hydrate–alkali results in oligomeric dichalcogenides,

Cu(ii) complexes with tridentate sulfur and selenium ligands: catecholase and hydrolysis activity

Two new copper(ii) mononuclear complexes (CSe and CS) were synthesized and characterized by the following techniques: X-ray crystallography, elemental analysis, IR, EPR and UV-vis spectroscopies, conductimetric analysis and mass spectrometry. The crystall

Ruthenium-catalyzed ester reductions applied to pharmaceutical intermediates

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (～5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs

Three new manganese carbonyl compounds with heavy atom donors were synthesized and their potential use as photoCORMS was evaluated. Interestingly, all compounds had an elusive binding mode, in which the ligands adopted a κ2-X coordination (wher

SNS-Ligands for Ru-Catalyzed Homogeneous Hydrogenation and Dehydrogenation Reactions

A detailed study of literature-known and novel S-containing pincer-type ligands for ruthenium-catalyzed homogeneous hydrogenation and dehydrogenation reactions was carried out. The scope and limitations of these catalysts were carefully investigated, and it was shown that simple bench-stable SNS-Ru complexes can be used to facilitate the hydrogenation of a variety of different substrates at a maximum H2 pressure of 20 bar under operationally simple, easy to scale up, glovebox-free conditions by using starting materials and reagents that do not require any special purification prior to use. It was also shown that such complexes can be used to catalyze the dehydrogenative coupling of alcohols and amines to get amides as well as for the dehydrogenative dimerization of alcohols to esters.

CATALYTIC HYDROGENATION PROCESS FOR THE SYNTHESIS OF TERMINAL DIOLS FROM TERMINAL DIALKYL ALIPHATIC ESTERS

A phosphorus ligand-free, mild, efficient and complete catalytic hydrogenation process is for the sustainable production of terminal diols from renewable terminal dialkyl esters with improved yield. Soluble, phosphorus ligand free Ru (II)-pincer type complexes can be used as catalysts in the hydrogenation process.

Sulfur nitrogen heteroatom ligand the application of the preparation and the ligand

The invention relates to a preparation method of a sulfur and nitrogen heteroatom ligand and application thereof in catalyst preparation and olefin polymerization. The preparation method comprises use of R1SR2X and ammonia for reaction in alkaline conditions to obtain (R1SR2)2NH, and the method provides a method for synthesizing the non-toxic or low-toxicity sulfur and nitrogen heteroatom ligand, simplifies the synthesis steps, and reduces the use of highly toxic chemicals in the testing process. In addition, the invention also relates to a preparation method of a chromium based catalyst for olefin oligomerization and application of the chromium based catalyst in ethylene trimerization, and the preparation method of the chromium based catalyst comprises the preparation method of the sulfur and nitrogen heteroatom ligand.

Palladium(ii)-(E,N,E) pincer ligand (E = S/Se/Te) complex catalyzed Suzuki coupling reactions in water via in situ generated palladium quantum dots

The (E,N,E) pincer ligands (ArECH2CH2)2NH (L1/L2: Ar = Ph, E = S/Se; L3: Ar = CH3O-p-C6H 4, E = Te) synthesized by reaction of PhS-/PhSe -/CH3O-p-C6/s

Highly selective and sensitive fluorescent turn-on chemosensor for AI 3+ based on a novel photoinduced electron transfer approach

A photoinduced electron transfer (PET)-based chemosensor possessing dual PET processes by simultaneously introducing both nitrogen and sulfur donors was achieved. The fluorescence signal of the free chemosensor is in a normal-off state due to the sulfur d

Chemistry of N-phosphorylated nitrogen mustards: The effect of a second nitrogen substituent at phosphorus on the stability of the system

Methyl N,N-diethyl-N′N′-bis(2-chloroethyl)phosphoramidate was prepared as a precursor for the corresponding phosphordiamidate anion, a model for the phosphoramidate mustard, biologically active degradation product of cyclophosphamide drug. Demethylation of the precursor led to a highly unstable ion which underwent spontaneous fragmentation. In the absence of an external nucleophile, the ion decomposed yielding metaphosphoramidate and N-substituted ethyleneimine as primary intermediates. In the presence of pyridine, bis-alkylation of two pyridines took place yielding bis [2-(N-pyridinio)ethyl]amine dication, in addition to some 1,3,2-oxazaphospholidine derivative, formed via the competitive 1,5-cyclization of the demethylated anion. Incubation of the precursor in the presence of thiophenol/triethylamine resulted in two parallel nucleophilic displacements: (i) the O-demethylation followed by bisalkylation of two molecules of thiophenol, together with some 1,5-cyclization; (ii) initial direct displacement of the chlorine at the β-carbon of the precursor, followed by the fragmentation of the system. It is concluded that the electron-rich ionic phosphoramidate substituent, -O(R2N)P(O), highly activates the N-(2-chloroethyl) functional group in alkylation reactions.