20168-88-1Relevant academic research and scientific papers
GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF
-
Paragraph 0432-0435, (2020/07/23)
The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like]
GRISEOFULVIN COMPOUND
-
Paragraph 0143; 0144; 0145, (2019/02/13)
An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.
Synthesis and single crystal X-ray analysis of two griseofulvin metabolites
R?nnest, Mads H.,Harris, Pernille,Gotfredsen, Charlotte H.,Larsen, Thomas O.,Clausen, Mads H.
experimental part, p. 5881 - 5882 (2010/12/24)
The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.
