20172-34-3

Basic information

• Product Name: Heptanamide, N-(4-methylphenyl)-
• Synonyms: heptanoic acid p-tolylamide;n-Heptoyl-p-toluidid;Oenanthsaeure-p-toluidid;Oenanth-p-toluidid;Heptansaeure-p-toluidid;heptanoic acid p-toluidide
• CAS NO: 20172-34-3
• Molecular Formula: C14H21NO
• Molecular Weight: 219.327
• Mol File: 20172-34-3.mol

Chemical Properties

• CAS DataBase Reference: Heptanamide, N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Heptanamide, N-(4-methylphenyl)-(20172-34-3)
• EPA Substance Registry System: Heptanamide, N-(4-methylphenyl)-(20172-34-3)

Safety Data

• Hazardous Substances Data: 20172-34-3(Hazardous Substances Data)

Upstream product

• 512173-24-9 heptanoic acid (4-methoxyphenyl)-amide 
• 106-49-0 p-toluidine 
• 56051-98-0 heptananilide 
• 111-14-8 oenanthic acid 
• 103-89-9 4-Methylacetanilide 
• 55917-07-2 heptanoic acid benzylamide 
• 543709-59-7 heptanoic acid (4-fluoro-phenyl)-amide 
• 331672-95-8 1H-1,2,3-benzotriazol-1-yl(n-hexyl)methanone 
• 2528-61-2 Heptanoic acid chloride 

Downstream Products

• 55917-07-2 heptanoic acid benzylamide 
• 103-89-9 4-Methylacetanilide 
• 512173-24-9 heptanoic acid (4-methoxyphenyl)-amide 
• 106-49-0 p-toluidine 
• 56051-98-0 heptananilide 
• 543709-59-7 heptanoic acid (4-fluoro-phenyl)-amide 

Relevant articles and documents

Direct amide bond formation from carboxylic acids and amines using activated alumina balls as a new, convenient, clean, reusable and low cost heterogeneous catalyst

For the first time, we have used activated alumina balls (3-5 mm diameter) for amide synthesis from carboxylic acids (unactivated) and amines (unactivated) under neat reaction conditions that produce no toxic by-products and has the advantages of being low-cost, easily available, heterogeneous, reusable and environmentally benign with no troublesome/hazardous disposal of the catalyst.

Catalytic metathesis of simple secondary amides

(Chemical Equation Presented) Trading places: The metathesis of secondary amides through a transacylation mechanism has been achieved by employing catalytic quantities of an organic imide and a Bronsted base (see scheme). Equilibrium-controlled exchange between various amide pairs is demonstrated for substrates bearing N-alkyl and N-aryl substituents.

Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles

Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.

Catalytic transamidation and amide metathesis under moderate conditions

Disclosed is a method of manipulating the carboxamide functionality in a catalytic manner. The method includes the steps of reacting amides with or without amines in the presence of various types of metal catalysts, at a temperature of about 250° C. or less.