201735-31-1Relevant academic research and scientific papers
Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes
Zhang, Yang,Torker, Sebastian,Sigrist, Michel,Bregovi?, Nikola,Dydio, Pawe?
supporting information, p. 18251 - 18265 (2020/11/02)
Since its discovery in 1938, hydroformylation has been thoroughly investigated and broadly applied in industry (>107 metric ton yearly). However, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many synthetically valuable aldehydes. Pd-catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-processes. Here, we report a highly selective and exceptionally active catalyst system that is driven by a novel activation strategy and features a unique Pd(I)-Pd(I) mechanism, involving an iodide-assisted binuclear step to release the product. This method enables β-selective hydroformylation of a large range of alkenes and alkynes, including sensitive starting materials. Its utility is demonstrated in the synthesis of antiobesity drug Rimonabant and anti-HIV agent PNU-32945. In a broader context, the new mechanistic understanding enables the development of other carbonylation reactions of high importance to chemical industry.
POLYCYCLIC RING-FUSED COMPOUND AND ORGANIC THIN FILM TRANSISTOR UTILIZING SAME
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Page/Page column 25, (2012/11/08)
A compound for an organic thin film transistor represented by the following formula (1):
Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
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Page/Page column 10, (2010/02/12)
Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.
Palladium-catalyzed desulfitative Sonogashira-Hagihara cross-couplings of arenesulfonyl chlorides and terminal alkynes
Dubbaka, Srinivas Reddy,Vogel, Pierre
, p. 1793 - 1797 (2007/10/03)
For the first time, conditions have been found for the palladium-catalyzed desulfitative carbon-carbon cross-coupling of arenesulfonyl chlorides with aryl- and alkylacetylenes. Pd2(dba)3/P(t-Bu)3 and CuI provide the best c
Alkynylation of benzonitriles via nickel catalyzed C-C bond activation
Penney, Jonathan M.,Miller, Joseph A.
, p. 4989 - 4992 (2007/10/03)
The scope of synthetically useful nickel catalyzed cross coupling reactions of benzonitriles has now been expanded to allow alkynylation. Thus, the cross coupling of benzonitriles with alkynylzinc reagents occurs readily in the presence of Ni/PMe3/s
