20180-31-8

Upstream product

• 83515-02-0 (Hydroxymethyl)methylphenylsilan 
• 101132-83-6 (Chlorformyloxymethyl)methylphenylsilan 
• 124-40-3 dimethyl amine 
• 768-33-2 phenyldimethylsilyl chloride 
• 766-77-8 Dimethylphenylsilane 

Downstream Products

• 1117-37-9 ethyl (E)-3-(dimethylamino)acrylate 
• 999-59-7 methyl (2E)-3-(dimethylamino)prop-2-enoate 
• 76710-50-4 [3-(Dimethyl-phenyl-silanyloxy)-propyl]-dimethyl-amine 
• 76710-49-1 <2-(Dimethylamino)ethoxy>dimethylphenylsilan 
• 68733-44-8 C₁₁H₁₇NS₂Si 

Relevant academic research and scientific papers

Aminosilylation of arynes with aminosilanes: Synthesis of 2-silylaniline derivatives

The nitrogen-silicon σ-bond of aminosilanes added across the triple bond of arynes to give varied 2-silylaniline derivatives straightforwardly. The Royal Society of Chemistry 2005.

Silicon-nitrogen bond formation by nucleophilic activation of silicon-hydrogen bonds

A method of forming Si-N bonds by dehydro-coupling of Si-H and N-H bonds in the presence of a nucleophilic catalyst is reported.The method is useful for the preparation of silylamines and silazanes and for crosslinking of organometallic polymers.

On the Thermal Behaviour of Some (Methylphenylsilyl)methyl Carbonate Derivatives

The synthesis and the thermal behaviour of the (methylphenylsilyl)methyl carbonates CH3(C6H5)Si(H)CH2OC(O)X (6: X = OCH3; 7: X = Cl; 8: X = N(CH3)2) is described. 8 rearranges in toluene solution at 100 deg C quantitatively to give the carbamoyloxysilane C6H5(CH3)2SiOC(O)N(CH3)2 (11), whereas neat 6 and 7 at 135 deg C undergo quantitative formation of C6H5(CH3)2SiOCH3 (12) and C6H5(CH3)2SiCl (13), respectively.The formation of 12 and 13 is explained by a rearrangement reaction (by analogy to the rearrangement of 8), followed by a decarboxylation.The thermally induced transformations 6-->12, 7-->13, and 8-->11 were found to be first-order reactions with half-lifes of ca. 2.6 h (135 deg C, neat), ca. 4.5 h (135 deg C, neat), and ca. 3.7 h (100 deg C, in toluene), respectively. - Keywords: (Methylphenylsilyl)methyl Carbonates, Rearrangement, Dimethylphenylsilyl Carbonates, Decarboxylation

246. Monofunctional (Dimethylamino)silane as Silylating Agent

The reaction of triorganyl(dimethylamino)silanes with surface-hydrated silicon dioxide has been studied.These silylating agents are easy to prepare from the corresponding chloro or bromosilanes with dimethylamine.The resulting products are thermally stable and relatively volatile.Reaction with surface-hydrated silicon-dioxide preparations at a50-250 deg C for 170 h yields a dense grafted layer.However, with (dimethylamino)silanes having strongly polar substituents, a retreatment of the surface-modified silica seems to be necessary in order to attain maximum coverage.

19-Hydroxy-PGI2 compounds

Prostacyclin and prostacyclin-type derivatives having a 19-hydroxy feature are disclosed, including processes for preparing them and the appropriate intermediates. The compounds are useful for pharmacological purposes such as inhibition of blood platelate aggregation.

2-Decarboxy-2-hydroxymethyl-19-hydroxy-PG1 analogs

Prostaglandin derivatives having a 19,20-didehydro, a 19-hydroxy, or a 19-keto feature are disclosed, including processes for preparing them and the appropriate intermediates. A typical 19-hydroxy compound of this invention is 19-hydroxy-19-methyl-PGF2α, methyl ester, represented by the formula STR1

Bicyclic lactones

Process for preparing bicyclic lactone acrylic aldehydes and ketones of the formula STR1 wherein "n" is one or 2, wherein R1, is hydrogen, methyl, or ethyl, and wherein R4 is hydrogen or a blocking group; and those aldehydes, ketones, and intermediates prepared therein. The aldehydes and ketones are useful intermediates in preparing prostaglandins and analogs having pharmacological utility.