201802-05-3

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 25026-34-0 4-chlorophenacetyl chloride 
• 121-88-0 5-Nitro-2-aminophenol 

Downstream Products

• 130769-07-2 2-(4-Chloro-phenyl)-N-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-acetamide 
• 118383-56-5 N-(4-amino-2-hydroxyphenyl)-2-(4-chlorophenyl)acetamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents

A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (1a-1n, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolate. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 μg/ml. Benzamide derivative 1d exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 μg/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively.

Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships

A new series of benzoxazole 2,4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity than known 2,4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2,4-thiazolidinediones was also established using aminophenol 2,4- thiazolidinedione (11) as a key intermediate. Details of synthesis and structure-activity relationships for this series are described.