201809-32-7 Usage
Uses
Used in Pharmaceutical Research:
8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole is used as a ligand in drug discovery for its potential to interact with biological targets. Its unique structure allows it to be a candidate for the development of new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole is utilized for the synthesis of novel compounds with potential therapeutic applications. Its pyrazinoindole ring system provides a foundation for the design of molecules with specific biological activities.
Used in Drug Development:
8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole is employed in drug development as a starting material or intermediate for creating new pharmaceuticals. Its properties may contribute to the discovery of drugs with improved efficacy, selectivity, and safety profiles.
Used in Chemical Synthesis:
8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole serves as a key intermediate in the synthesis of complex organic molecules, particularly those with potential applications in the pharmaceutical and chemical industries.
Used in Biochemical Studies:
8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole is also used in biochemical studies to understand its interactions with various biological systems, which can provide insights into its potential therapeutic effects and mechanisms of action.
Used in Drug Screening:
8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole is utilized in high-throughput screening assays to identify its potential as a lead compound for the treatment of various diseases and conditions.
Used in Neuropharmacology:
Given the presence of the indole ring, which is common in many psychoactive compounds, 8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole may be used in neuropharmacology to explore its effects on the central nervous system and its potential use in the treatment of neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 201809-32-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,8,0 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 201809-32:
(8*2)+(7*0)+(6*1)+(5*8)+(4*0)+(3*9)+(2*3)+(1*2)=97
97 % 10 = 7
So 201809-32-7 is a valid CAS Registry Number.
201809-32-7Relevant academic research and scientific papers
hERG Optimization of Benzofuro?Pyridine and Pyrazino?Indole Derivatives as MCHR1 Antagonists
Beke, Gyula,Katalin Szalai, Krisztina,éles, János,Boros, András,Bozó, éva,Greiner, István,Huszár, József,Kardos, Péter
, (2022/02/10)
Obesity is a global epidemic associated with multiple severe diseases. Several pharmacotherapies have been investigated including the antagonists of melanin concentrating hormone receptor 1 (MCHR1). The design, synthesis, and biological studies of novel MCHR1 antagonists based on benzofuro?pyridine and pyrazino?indole scaffold was performed. We confirmed that fine-tuning lipophilicity and basic pKa by modifying the benzyl group and introducing different substituents on the aliphatic nitrogen sidechain decreases both hERG inhibition and metabolic clearance. We have succeeded to develop excellent in vitro parameters in the case of compounds 17 (4-[(5-chloropyridin-2-yl)methoxy]-1-[4-(2-hydroxyethyl)-8-oxa-4-azatricyclo[7.4.0.02,7]trideca-1(13),2(7),9,11-tetraen-11-yl]-1,2-dihydropyridin-2-one monohydrochloride) and 23 g (4-[(5-chloropyridin-2-yl)methoxy]-1-(1,2,3,4-tetrahydropyrazino[1,2-a]indol-8-yl)pyridin-2(1H)-one monohydrochloride), which can be considered as valuable tools for further pharmacological investigation.
