201811-58-7

Basic information

• Product Name: tert-butyl 2-chloro-4-hydroxyphenylcarbamate
• Synonyms: tert-butyl 2-chloro-4-hydroxyphenylcarbamate;(2-chloro-4-hydroxy-phenyl)carbamic acid tert-butyl ester;Intermediate of Lenvatinib
• CAS NO: 201811-58-7
• Molecular Formula: C₁₁H₁₄ClNO₃
• Molecular Weight: 243.68676
• EINECS: -0
• Mol File: 201811-58-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 309.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.290±0.06 g/cm3(Predicted)
• PKA: 9.22±0.31(Predicted)
• CAS DataBase Reference: tert-butyl 2-chloro-4-hydroxyphenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-chloro-4-hydroxyphenylcarbamate(201811-58-7)
• EPA Substance Registry System: tert-butyl 2-chloro-4-hydroxyphenylcarbamate(201811-58-7)

Safety Data

• Hazardous Substances Data: 201811-58-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 52671-64-4 4-Amino-3-chlorophenol hydrochloride 
• 17609-80-2 4-amino-3-chlorophenol 
• 108-43-0 3-monochlorophenol 

Downstream Products

• 946885-00-3 2-chloro-4-(1,3-thiazol-2-yloxy)aniline 
• 417716-92-8 lenvatinib 
• 929118-54-7 N-(4-(2-(4-amino-3-chlorophenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamide 
• 929118-53-6 4-(5-bromothiazol-2-yloxy)-2-chloroaniline 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

Tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity and chemoselectivity of this novel Boc reagent. The reaction was carried out chemoselectively in high yield under mild, environment-friendly conditions and was completed quickly within 1 hour. Simultaneously, the Boc carrier was easily recyclable, and has great application prospects for industrial production.

A method for preparing le Fati Nepal

The invention discloses a preparation method of lenvatinib. The preparation method comprises the following steps : adopting 4-amino-3-irgasan as a starting material, firstly adopting amino groups for protection, then carrying out butt jointing with 4-chloro-7-methoxyquinoline-6-amide, removing amino-group protective groups, reacting with cyclopropylamine and preparing to obtain the lenvatinib. The preparation method disclosed by the invention is simple and easy to implement, high in yield, good in quality and convenient in industrial production.