17609-80-2

Basic information

• Product Name: 4-Amino-3-chlorophenol
• Synonyms: AMINO(4-)-3-CHLOROPHENOL;4-AMINO-3-CHLOROPHENOL;3-chloro-4-aminophenol;4-amino-3-chloro-pheno;Brn 2802558;Einecs 241-583-3;Phenol, 4-amino-3-chloro-;lenvaint-G
• CAS NO: 17609-80-2
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: 241-583-3
• Mol File: 17609-80-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 159-160℃
• Boiling Point: 287.3°Cat760mmHg
• Flash Point: 127.6°C
• Appearance: White/Crystalline Powder
• Density: 1.406g/cm³
• Vapor Pressure: 0.00074mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.26±0.18(Predicted)
• CAS DataBase Reference: 4-Amino-3-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-chlorophenol(17609-80-2)
• EPA Substance Registry System: 4-Amino-3-chlorophenol(17609-80-2)

Safety Data

• RTECS: SJ5710000
• HazardClass: 6.1
• Hazardous Substances Data: 17609-80-2(Hazardous Substances Data)

Usage

Description

4-Amino-3-chlorophenol is an organic compound characterized by its light yellow solid appearance. It is known for its chemical structure that includes an amino group at the 4th position and a chlorine atom at the 3rd position on a phenol ring.

Uses

Used in Pharmaceutical Industry:
4-Amino-3-chlorophenol is used as a synthetic reagent for the preparation of Benzothiazole-based ureas. These compounds have potential as modulators for ABAD/17β-HSD10, which are targets in the treatment of Alzheimer's disease. The development of such modulators can contribute to the advancement of therapeutic strategies for this neurodegenerative condition.

InChI:InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2

Upstream product

• 7664-93-9 sulfuric acid 
• 7758-99-8 copper(II) sulfate 
• 88-73-3 2-Chloronitrobenzene 
• 95-51-2 o-chloroaniline 
• 123-30-8 4-amino-phenol 
• 2623-33-8 4-acetoxyacetanilide 
• 7647-01-0 hydrogenchloride 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 
• 20815-53-6 4-(4-chlorophenylazo)pyridine 
• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 74993-54-7 O-(m-chloro-phenyl)-hydroxylamine 
• 60144-85-6 4'-acetoxy-2'-chloroacetanilide 
• 491-11-2 3-chloro-4-nitrophenol 

Downstream Products

• 695-99-8 2-Chloro-1,4-benzoquinone 
• 919278-23-2 2-chloro-4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)aniline 
• 919278-09-4 2-chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-oxy]aniline 
• 919278-43-6 4-(4-amino-3-chlorophenoxy)-6-iodopyrimidine-5-amine 
• 919278-10-7 2-chloro-4-[(5-ethyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]aniline 
• 919278-41-4 2-chloro-4-{[6-(2-furyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]oxy}aniline 
• 919278-12-9 2-{2-[4-(4-amino-3-chlorophenoxy)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethyl benzoate 
• 919278-42-5 tert-butyl {2-[4-(4-amino-3-chlorophenoxy)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}carbamate 
• 919278-46-9 4-(4-amino-3-chlorophenoxy)-6-iodo-N-methylpyrimidin-5-amine 
• 919278-14-1 2-chloro-4-({5-[2-(2-methoxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}oxy)aniline 
• 919278-52-7 4-(4-amino-3-chlorophenoxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-6-carbonitrile 
• 919278-54-9 2-[4-(4-amino-3-chlorophenoxy)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]acetamide 
• 919278-17-4 2-chloro-4-{[5-(2-methoxyethyl)-5H-pyrrolo[3,2-d]pyrimidin-4-yl]oxy}aniline 
• 417722-05-5 4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine 

Relevant articles and documents

Hydroxylation of aromatic amines with dioxygen in photooxidation sensitized by substituted phthalocyanines

Photooxidation of aniline and its methyl and chloro derivatives with dioxygen sensitized by substituted zinc (PcZn) and palladium (PcPd) phthalocyanines in solution and on the carrier surface upon visible light irradiation affords selectively the corresponding p-aminophenols. Active and the most stable PcPd derivative adsorbed on Amberlite XAD 7HP provides conversion of 2,6-dimethylaniline with selectivity over 90% without the loss of sensitizer activity at least in 8 repeated cycles, the overall turnover number of the sensitizer being greater than 25,000.

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The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.