17609-80-2

Basic information

• Product Name: 4-Amino-3-chlorophenol
• Synonyms: AMINO(4-)-3-CHLOROPHENOL;4-AMINO-3-CHLOROPHENOL;3-chloro-4-aminophenol;4-amino-3-chloro-pheno;Brn 2802558;Einecs 241-583-3;Phenol, 4-amino-3-chloro-;lenvaint-G
• CAS NO: 17609-80-2
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: 241-583-3
• Mol File: 17609-80-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 159-160℃
• Boiling Point: 287.3°Cat760mmHg
• Flash Point: 127.6°C
• Appearance: White/Crystalline Powder
• Density: 1.406g/cm³
• Vapor Pressure: 0.00074mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.26±0.18(Predicted)
• CAS DataBase Reference: 4-Amino-3-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-chlorophenol(17609-80-2)
• EPA Substance Registry System: 4-Amino-3-chlorophenol(17609-80-2)

Safety Data

• RTECS: SJ5710000
• HazardClass: 6.1
• Hazardous Substances Data: 17609-80-2(Hazardous Substances Data)

Usage

Description

4-Amino-3-chlorophenol is an organic compound characterized by its light yellow solid appearance. It is known for its chemical structure that includes an amino group at the 4th position and a chlorine atom at the 3rd position on a phenol ring.

Uses

Used in Pharmaceutical Industry:
4-Amino-3-chlorophenol is used as a synthetic reagent for the preparation of Benzothiazole-based ureas. These compounds have potential as modulators for ABAD/17β-HSD10, which are targets in the treatment of Alzheimer's disease. The development of such modulators can contribute to the advancement of therapeutic strategies for this neurodegenerative condition.

InChI:InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2

Upstream product

• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 20815-53-6 4-(4-chlorophenylazo)pyridine 
• 7664-93-9 sulfuric acid 
• 7758-99-8 copper(II) sulfate 
• 88-73-3 2-Chloronitrobenzene 
• 95-51-2 o-chloroaniline 
• 123-30-8 4-amino-phenol 
• 2623-33-8 4-acetoxyacetanilide 
• 7647-01-0 hydrogenchloride 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 
• 74993-54-7 O-(m-chloro-phenyl)-hydroxylamine 
• 60144-85-6 4'-acetoxy-2'-chloroacetanilide 
• 491-11-2 3-chloro-4-nitrophenol 

Downstream Products

• 695-99-8 2-Chloro-1,4-benzoquinone 
• 88680-97-1 benzenesulfonic acid-(2-chloro-4-hydroxy-anilide) 
• 156079-17-3 2-[(4-Benzyloxy-2-chloro-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol 
• 156079-23-1 (4-Benzyloxy-2-chloro-phenyl)-bis-(2-chloro-ethyl)-amine 
• 172974-06-0 Carbonic acid 4-[bis-(2-chloro-ethyl)-amino]-3-chloro-phenyl ester 4-nitro-phenyl ester 
• 172974-13-9 (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-3-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester 
• 122267-40-7 2-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)-ethoxy]-aniline 
• 1097211-45-4 C₂₅H₂₆Cl₂N₂O₃ 
• 1097211-34-1 C₂₉H₃₄Cl₂N₂O₃ 
• 1097211-14-7 C₂₉H₃₄ClFN₂O₃ 
• 1097211-40-9 C₂₈H₃₂ClFN₂O₃ 
• 1097210-76-8 C₂₃H₂₄Cl₂N₂O₂ 
• 417724-70-0 N₆-Methoxy-4-(4-amino-3-chlorophenoxy)-7-benzyloxy-6-quinolinecarboxamide 
• 417724-68-6 N₆-Ethyl-4-(4-amino-3-chlorophenoxy)-7-benzyloxy-6-quinolinecarboxamide 

Relevant articles and documents

Hydroxylation of aromatic amines with dioxygen in photooxidation sensitized by substituted phthalocyanines

Photooxidation of aniline and its methyl and chloro derivatives with dioxygen sensitized by substituted zinc (PcZn) and palladium (PcPd) phthalocyanines in solution and on the carrier surface upon visible light irradiation affords selectively the corresponding p-aminophenols. Active and the most stable PcPd derivative adsorbed on Amberlite XAD 7HP provides conversion of 2,6-dimethylaniline with selectivity over 90% without the loss of sensitizer activity at least in 8 repeated cycles, the overall turnover number of the sensitizer being greater than 25,000.

Method for synthesizing 4-amino-3-chlorophenol by means of multiple-temperature-zone continuous flow microchannel reactor

The invention relates to a method for synthesizing 4-amino-3-chlorophenol by means of a multiple-temperature-zone continuous flow microchannel reactor, which belongs to the field of organic synthesisof anti-cancer drugs, and solves the problems in the prior art that in a process of synthesizing 4-amino-3-chlorophenol, the product yield is low, the purity is low, the cost is high and the safety property of the product is poor and the like as raw materials are not easily available, the catalyst is high in cost and the synthesized intermediate product is unstable in diazonium salt. By means of the microchannel reactor, sulfanilic acid is taken as an initial raw material, a target product 4-amino-3-chlorophenol is obtained by three steps of diazotization, coupling of diazonium salt and reduction of an azoic compound. The method provided by the invention can be applied to large-scale production of 4-amino-3-chlorophenol.

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.