201815-23-8

Basic information

• Product Name: (1R,2S,3R,4S)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid monoisopropyl ester
• Synonyms: (1R,2S,3R,4S)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid monoisopropyl ester
• CAS NO: 201815-23-8
• Molecular Weight: 226.229
• Mol File: 201815-23-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,2S,3R,4S)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid monoisopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3R,4S)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid monoisopropyl ester(201815-23-8)
• EPA Substance Registry System: (1R,2S,3R,4S)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid monoisopropyl ester(201815-23-8)

Safety Data

• Hazardous Substances Data: 201815-23-8(Hazardous Substances Data)

Upstream product

• 6118-51-0 exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 
• 555-31-7 aluminum isopropoxide 

Relevant articles and documents

Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides to Isopropyl Hemiesters with Ti-TADDOLates: An Alternative to Hydrolytic Enzymes?

The Lewis acid mediated transfer of an alkoxide ligand from the chiral ligand sphere of Ti - TADDOLate (1) to cyclic meso anhydrides to afford the corresponding hemiesters is described. By using this method a variety of structurally different anhydrides can be converted to isopropyl hemiesters with high enantioselectivities (enantiomer ratios up to 99:1). We have also investigated Lewis acidic titanium complexes, which differ from 1 in the chiral ligand or the alkoxide ligand that is transferred. Finally, a catalytic version, which allows the substoichiometric use of Ti- TADDOLate in the presence of stoichiometric amounts of Al(Oi-Pr)3, is presented.