201815-81-8

Upstream product

• 50-98-6 ephedrine hydrochloride 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 475212-00-1 (1R,2S)-2-((4-bromobenzyl)methylamino)-1-phenyl-1-[(t-butyldimethylsilyl)oxy]propane 
• 130647-17-5 (1R,2S)-(-)-2-(methylamino)-1-phenyl-1<(tert-butyldimethylsilyl)oxy>-propane 

Downstream Products

• 242481-85-2 (1R,2S)-2-[Methyl-(4-trimethylsilanylethynyl-benzyl)-amino]-1-phenyl-propan-1-ol 
• 201815-83-0 (1R,2S)-2-({4-[((E)-2-{[1-(4-{[((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenyl)-meth-(E)-ylidene]-amino}-ethylimino)-methyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol 
• 399566-85-9 (1R,2S)-2-{[4-(3,5-Dibromo-phenylethynyl)-benzyl]-methyl-amino}-1-phenyl-propan-1-ol 
• 223922-32-5 (1R,2S)-2-[(4-Ethynyl-benzyl)-methyl-amino]-1-phenyl-propan-1-ol 
• 475212-00-1 (1R,2S)-2-((4-bromobenzyl)methylamino)-1-phenyl-1-[(t-butyldimethylsilyl)oxy]propane 
• 201815-82-9 4-{[((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-benzaldehyde 

Relevant academic research and scientific papers

Synthesis and preliminary studies on a novel class of soluble amino alcohol reagents based on methacrylate copolymers

A class of soluble polymers containing chiral β-amino alcohol ligands, based on methacryate copolymers, are described. The use of copolymers permits the selective introduction of material to control the solubility and a functional group in a controllable ratio and polymer length. The application of the supported polymers to diethylzinc additions is described.

Highly enantioselective addition of dialkylzincs to aldehydes using dendritic chiral catalysts with flexible carbosilane backbones

Chiral dendrimers bearing four or twelve chiral β-amino alcohols on the hyperbranched flexible carbosilane chain-ends act as efficient chiral catalysts for the enantioselective addition of dialkylzinc to aldehydes to afford enantiomerically enriched sec-alcohols with up to 93% e.e.