201856-57-7

Basic information

• Product Name: (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate
• Synonyms: 3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-dimethylethyl ester;(3r,4s)-tert-butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate;(3R,4S)-1-AZETIDINECARBOXYLIC ACID-3-(2-ETHOXYETHOXY)-4-PHENYL-2-PHENYL-AZETIDIONE;(3R,4S)-1-t-butoxycarbonyl-3-(2-ethoxyethoxyl)-4-phenyl-2-azetidinone;(3R,4S)-1-T-BUTOXYCARBONYL-3-(2-ETHOXYETHOXYL)-4-PHENYL-2-AZETIDINONE,98+%;SIDE CHAINS OF DOCETAXEL--1;(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-dimethyl ethyl ester;(3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic Acid 1,1-DiMethylethyl Ester
• CAS NO: 201856-57-7
• Molecular Formula: C₁₈H₂₅NO₅
• Molecular Weight: 335.39
• EINECS: 1592732-453-0
• Mol File: 201856-57-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 459.592 °C at 760 mmHg
• Flash Point: 231.753 °C
• Appearance: /
• Density: 1.16
• Vapor Pressure: 1.25E-08mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• PKA: -4.97±0.60(Predicted)
• CAS DataBase Reference: (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate(201856-57-7)
• EPA Substance Registry System: (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate(201856-57-7)

Safety Data

• Hazardous Substances Data: 201856-57-7(Hazardous Substances Data)

Usage

Uses

(3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is used as a reagent in the synthesis of abeo-taxane derivatives that possess broad inhibitory effects against proliferation of colon cancer, melanoma, and renal cancer cell lines. (3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is also used as a reagent in the synthesis of a novel D-ring modified Docetaxel (D494420) analogue which has proven to have equipotent cytotoxicity in relation to Paclitaxel (P132500) towards cancer cell lines.

InChI:InChI=1/C18H25NO5/c1-6-22-12(2)23-15-14(13-10-8-7-9-11-13)19(16(15)20)17(21)24-18(3,4)5/h7-12,14-15H,6H2,1-5H3

Upstream product

• 201856-567-7 (3R,4S)-1-AzetidinecarboxylicAcid-3-(2-Ethoxyethoxy)-4-Phenyl-2-Phenyl-AzetidioneCasNo. 
• 201856-53-3 (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone 
• 201856-48-6 (3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone 
• 201855-71-2 trans 1-Benzyl-4-(4-fluorophenyl)-3-methylsulfonatepiperidine 
• 201855-60-9 trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol 
• 201855-53-0 H-SER-TYR-AMC 
• 20185-55-1 METHYL 4-ISOPROPYLBENZOATE 
• 201855-41-6 H-SER(TBU)-AMC HCL 
• 20185-43-7 4-Pyrimidinecarboxaldehyde, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo- 
• 201854-09-3 H-ORN-AMC 2 HCL 
• 201854-07-1 H-MET-AMC ACETATE SALT 
• 201854-05-9 MEOSUC-GLY-LEU-PHE-AMC 
• 201853-92-1 MEOSUC-ALA-PHE-LYS-AMC TFA 
• 201853-55-6 MEOSUC-ALA-ALA-PRO-MET-AMC 

Downstream Products

• 201857-39-8 4-AMINO-3-BROMO-5-CHLOROBENZONITRILE 
• 201858-22-2 2-(4-chloroanilino)-4-oxo-4-phenylbutanoic acid 
• 201858-51-7 4-(4-DiMethylaMinophenylazo)benzoic acid 
• 20185-96-0 2-pyrrolidin-1-ylethyl 2-phenylbicyclo[2.2.1]heptane-2-carboxylate hydrochloride 
• 201860-17-5 BACLIGHT(TM) GREEN BACTERIAL STAIN 
• 201860-29-9 SUC-TYR-VAL-ALA-ASP-AMC 
• 201860-40-4 H-THR(TBU)-AMC HCL 
• 201860-49-3 L-TRYPTOPHAN 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 
• 2018-61-3 N-Acetyl-L-phenylalanine 
• 201861-91-8 4,4''-DIIODO-TRANS-STILBENE 
• 20186-22-5 pisatin 
• 20186-29-2 Magnolioside 
• 201863-97-0 (4R)-4-AMINO-4-PHENYLBUTANOIC ACID 
• 201863-98-1 (S)-4-Amino-4-phenylbutyric acid 

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