201860-69-7

Upstream product

• 329327-17-5 C₅₂H₅₂O₁₈ 
• 201860-63-1 1,3,4,5,6-Penta-O-(p-anisoyl)-myo-inositol 
• 201860-64-2 2-O-(4-Methoxytetrahydropyran-4-yl)-myo-inositol 
• 17327-22-9 4-methoxy-2,6-dihydropyran 
• 15356-62-4 L-menthoxyacetyl chloride 

Downstream Products

• 201860-73-3 6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-2-O-(4-methoxytetrahydropyran-4-yl)-L-myo-inositol 
• 24558-77-8 3,4,5,6-tetra-O-benzyl inositol 
• 201860-74-4 3,4,5-Tris-O-[(4-chlorophenoxy)acetyl]-6-O-{2,7-dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-2-O-(4-methoxytetrahydropyran-4-yl)-L-myo-inositol 

Relevant academic research and scientific papers

Synthesis of naturally occurring phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and its diastereoisomers

The chemical synthesis of naturally occurring phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3] and its diastereoisomers was discussed. In the first stage, the preparation of the required enantiomeric 1,2-di-O-acylglycerol derivatives was done. The second stage involved the preparation of suitably protected enantiomeric myo-inositol 1-phosphates. The glycerol and inositol building blocks were coupled together and the 3-, 4- and 5-hydroxy functions of the inositol residues in the coupled products were phosphorylated. Finally, the protecting groups were removed to give PtdIns(3,4,5)P3 and its diastereoisomers.

Synthesis of 1-O-stearoyl-2-O-arachidonoyl-sn-glycer-3-yl-D-myo-inositol 3,4,5-trisphosphate and its stereoisomers

The chemical synthesis of PtdIns(3,4,5)P3 2 and three of its stereoisomers is described.