201864-00-8

Basic information

• Product Name: (S)-2-amino-3-(4-chlorophenyl)propan-1-ol
• Synonyms: (S)-2-amino-3-(4-chlorophenyl)propan-1-ol;(S)-b-AMino-4-chlorobenzenepropanol;(S)-beta-Amino-4-chlorobenzenepropanol;2(S)-Amino-3-(4-chlorophenyl)propanol
• CAS NO: 201864-00-8
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.65068
• Mol File: 201864-00-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-amino-3-(4-chlorophenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-3-(4-chlorophenyl)propan-1-ol(201864-00-8)
• EPA Substance Registry System: (S)-2-amino-3-(4-chlorophenyl)propan-1-ol(201864-00-8)

Safety Data

• Hazardous Substances Data: 201864-00-8(Hazardous Substances Data)

Usage

General Description

(S)-2-amino-3-(4-chlorophenyl)propan-1-ol, also known as S-AMPH, is a chemical compound that belongs to the class of organic compounds known as phenylpropanes. It is a chiral compound, meaning it has a non-superimposable mirror image, and is commonly used as a precursor in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis and as a building block for the production of various compounds. The compound has a 4-chlorophenyl group attached to a three-carbon chain with an amino and hydroxyl group, making it a versatile molecule with potential applications in various industries.

Upstream product

• 35373-63-8 (R,S)-2-amino-3-p-chlorophenyl-1-propanol 
• 14173-39-8 p-chlorophenylalanine 
• 68759-85-3 para-chlorophenylalanine methyl ester 

Relevant articles and documents

SUBSTITUTED AMINO TRIAZOLES USEFUL AS CHITINASE INHIBITORS

Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

New thiazole carboxamides as potent inhibitors of Akt kinases

A new series of 2-substituted thiazole carboxamides were identified as potent pan inhibitors against all three isoforms of Akt (Akt1, Akt2 and Akt3) by systematic optimization of weak screening hit N-(1-amino-3-phenylpropan-2-yl)- 2-phenylthiazole-5-carboxamide (1). One of the most potent compounds, 5m, inhibited the kinase activities of Akt1, Akt2 and Akt3 with IC50 values of 25, 196 and 24 nM, respectively. The compound also potently inhibited the phosphorylation of downstream MDM2 and GSK3β proteins, and displayed strongly antiproliferative activity in prostate cancer cells. The inhibitors might serve as lead compounds for further development of novel effective anticancer agents.