68759-85-3

Upstream product

• 67-56-1 methanol 
• 14173-39-8 p-chlorophenylalanine 

Downstream Products

• 1190934-03-2 C₃₂H₅₀ClN₅O₅ 
• 1190934-02-1 C₁₆H₂₃ClN₂O₃ 
• 1195949-89-3 C₂₁H₃₁ClN₂O₅ 
• 51301-86-1 Boc-p-chloro-L-Phe-OH 
• 1144503-30-9 dimethyl 3,4-bis(4-chlorophenyl)-1H-pyrrole-2,5-dicarboxylate 
• 1613289-88-5 dimethyl 3-(4-chlorophenyl)-4-phenyl-1H-pyrrole-2,5-dicarboxylate 
• 201864-00-8 (1S)-1-(4-chlorophenylmethyl)-2-hydroxyethylamine 

Relevant academic research and scientific papers

X???X Halogen Bond-Induced Supramolecular Helices

The halogen bond is the attractive interaction between the electrophilic region of a halogen atom and the nucleophilic region of another molecular entity, emerging as a favorable manner to manipulate supramolecular chirality in self-assemblies. Engineerin

Effect of the 4′-substituted phenylalanine moiety of sansalvamide A peptide on antitumor activity

Eight sansalvamide A peptide analogues with 4′-fluoride, 4′-chloride, 4′-bromide, 4′-iodide, and 4′- methoxyphenylalanine moieties were synthesized. The effect of these para-substitutions of sansalvamide A peptide on their cytotoxicity was evaluated using HCT-116, MDA-MB-231, HT-29, HCT-15, K562, HeLa, and A549 cell lines. The 4′-methoxyphenylalanine analog of sansalvamide A peptide was found to be a promising antitumor agent.

HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.