201864-30-4

Upstream product

• 124-38-9 carbon dioxide 
• 201864-27-9 N-((2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-chloro-tetrahydro-pyran-3-yl)-acetamide 
• 79781-69-4 2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-galactopyranose 
• 4171-72-6 2-acetamido-2-deoxy-3,4,6-tri-O-benzyl-D-galactopyranose 

Downstream Products

• 260551-10-8 3-acetamido-2,6-anhydro-4,5,7-tri-O-benzyl-3-deoxy-D-glycero-L-gluco-heptonic acid methyl ester 
• 260551-12-0 3-acetamido-2,6-anhydro-4,5,7-tri-O-benzyl-3-deoxy-1-hydroxy-D-glycero-L-gluco-heptitol 
• 260551-15-3 (3-acetamido-2,6-anhydro-4,5,7-tri-O-benzyl-3-deoxy-D-glycero-L-gluco-heptitol-1-yl) di-O-benzyl phosphate 

Relevant academic research and scientific papers

Synthesis of Novel Donor Mimetics of UDP-Gal, UDP-GlcNAc, and UDP-GalNAc as Potential Transferase Inhibitors

For the enzymatic transfer of galactose, N-acetylglucosamine, and N-acetylgalactosamine, UDP-Gal (1), UDP-GlcNAc (2), and UDP-GalNAc (3) are employed, and UDP serves as a feedback inhibitor. In this paper the synthesis of the novel UDP-sugar analogues 4, 5, and 6 as potential transferase inhibitors is described. Compounds 4-6 feature C-glycosidic hydroxymethylene linkages between the sugar and nucleoside moieties in contrast to the anomeric oxygens in the natural derivatives 1-3.

C-glycosides: A stereoselective synthesis of α-C-galactosamines with a glycosyl dianion

α-C-glycosides of the galactosamine can be obtained from the configurationally stable α-glycosyl dianion which can be prepared by reductive lithiation of the chloride. Different electrophiles react selectively at the anomeric center.