2019-20-7Relevant articles and documents
Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase
Wu, Yuen-Jen,Liao, Chen-Chieh,Jen, Cheng-Hung,Shih, Yu-Chiao,Chien, Tun-Cheng
scheme or table, p. 4821 - 4823 (2010/08/22)
The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.