201938-49-0Relevant academic research and scientific papers
Synthesis of 5-chloromethylene hydantoins and thiohydantoins
Cernak, Timothy A.,Gleason, James L.
, p. 117 - 134 (2008/02/02)
5-Chloromethylene hydantoins were prepared by condensation of ureas with chloropyruvic acid. 5-Chloromethylene thiohydantoins were prepared by chlorination of dehydroalanines followed by condensation with thiophosgene. Convenient methods for formation of
Solid-phase synthesis of dehydroalanine derivatives
Yamada, Masaki,Miyajima, Tadatoshi,Horikawa, Hiroshi
, p. 289 - 292 (2007/10/03)
A novel solid-phase synthetic method for dehydroalanines and dehydropeptides has been developed. Elimination of the sulfone part with concomitant release from the solid support afforded the desired dehydroalanine derivatives. The products were given in good yields and excellent purities.
