20210-14-4

Usage

Physical state

Colorless liquid

Odor

Slightly sweet

Usage

Synthesis of pharmaceuticals and other organic compounds

Reagent in organic synthesis

Ability to form strong carbon-carbon bonds

Solubility

High in organic solvents

Toxicity

Relatively low

Importance

Building block for production of various products in pharmaceutical, agricultural, and chemical industries.

Upstream product

• 10226-29-6 6-Bromo-2-hexanone 
• 107-21-1 ethylene glycol 
• 1462-03-9 1-methylcyclopentanol 
• 10226-28-5 ethyl 6-methyl-3,4-dihydro-2H-pyran-5-carboxylate 
• 109-49-9 5-Hexen-2-one 

Downstream Products

• 160481-86-7 3,3-Dimethyl-1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-2-oxo-cyclohexanecarboxylic acid methyl ester 
• 324012-40-0 (3aS,6aR)-1,3-Dibenzyl-4-(5-oxohexylidene)tetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one 
• 30502-73-9 2,8-nonanedione 
• 1093945-49-3 2-(5-ethylenedioxyhexyl)cyclohex-2-enone 
• 1163253-69-7 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-4-nitro-1H-pyrazole 
• 1505447-92-6 ethyl 1-(4-((7-(2-methyl-1,3-dioxolan-2-yl)hept-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate 
• 1505447-85-7 2-(7-(4-iodophenoxy)hept-5-yn-1-yl)-2-methyl-1,3-dioxolane 
• 1416352-43-6 (R)-tert-butyl 2-(diphenylmethyleneamino)-6-(2-methyl-1,3-dioxolan-2-yl)hexanoate 
• 1161774-71-5 2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-4-nitro-2H-[1,2,3]triazole 
• 136429-52-2 nona-6t,8-dien-2-one 
• 131711-70-1 1α,3β-dihydroxy-20(S)-(5-hydroxy-5-methylhexyloxy)-9,10-secopregna-5,7,10(19)-triene 

Relevant academic research and scientific papers

INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN

Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions.

AMINOPYRAZOLE DERIVATIVES

The invention relates to aminopyrazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS

The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.

Long-range stereo-relay: Relative and absolute configuration of 1,n-glycols from circular dichroism of liposomal porphyrin esters

The relative and absolute configurations of long-chain syn- and anti-1,5-, 1,7- and 1,9-glycols were determined from exciton-coupled circular dichroism (ECCD) of the corresponding bis-5-(4′-carboxyl)-5,10,15,20-tetraphenylporphyrin esters measured in uniform (φ = 26 nm), unilamellar liposomes. Long-range transmission of configuration by ECCD is made possible through partial ordering of glycol ester-lipid molecules by liposomal bilayers. Copyright

An efficient and enantioselective synthesis of d-biotin

An efficient and enantioselective synthesis of d-biotin 1 starting from cis-1,3-dibenzyl-2-imidazo-lidone-4,5-dicarboxylic acid (6) is described. The key steps are the enantioselective reduction of meso-1,2-dicarboxylic thioanhydride 8 to prepare the (3as, 6ar)- thiolactone 9 and the introduction of the C6 side chain at C-2 in 9 via a modified Grignard reaction. This novel synthesis proceeded in six steps to afford 1 with 21% overall yield.