202145-90-2Relevant academic research and scientific papers
Practical synthesis of unsymmetrical polyamine amides
Blagbrough, Ian S.,Geall, Andrew J.
, p. 439 - 442 (1998)
Desymmetrisation of readily available symmetrical polyamines is an important first step in the synthesis of many polyamine containing natural products. Likewise in the synthesis of polyamine amides which are potentially useful for gene delivery and as neuroprotectants, based upon channel blocking toxins found in certain wasp and spider venoms. The application of trifluoroacetyl as a protecting group allows unsymmetrical polyamine amides to be easily prepared on a gram scale.
DNA condensation by cholesterol polyamine carbamates: A first step in gene therapy
Geall, Andrew J.,Blagbrough, Ian S.
, p. 145 - 150 (2007/10/03)
Novel cholesterol polyamine carbamates were prepared and their pKa values determined potentiometrically. Using the Henderson-Hasselbach equation, their charge, at physiological pH, was determined. Binding affinity for calf thymus DNA was measured using an
