202188-53-2Relevant academic research and scientific papers
Stereoselective synthesis of 5-alkyliden-6-aminotetrahydro-2-pyranones through an unexpected isomerization of the hydroxytetrahydro-2-pyridinones obtained by the selective reduction of acylated enaminones
Cimarelli, Cristina,Palmieri, Gianni
, p. 915 - 926 (2007/10/03)
A convenient methodology for the stem selective preparation of 5- alkyliden-6-aminotetrahydro-2-pyranone 4 is reported. The synthesis of 2- pyranone 4 occurs through an unknown isomerization mechanism of the hydroxytetrahydro-2-pyridinone 3 an accessible starting material obtained by mild and selective reduction of the 5-acyltetrahydro-2-pyridinone 2. The isomerization mechanism and the stereoselectivity in the synthesis of 2- pyranone 4 was investigated and rationalized.
