202199-03-9

Usage

Uses

Used in Pharmaceutical Industry:
(1-PHENYLETHYL)PYRIDIN-2-YLMETHYL-AMINE is used as a key component in the development of centrally acting drugs, particularly for the treatment of central nervous system disorders. Its presence in these drugs is attributed to its ability to modulate behavioral effects, making it a promising candidate for therapeutic intervention in various neurological conditions.
Used in Neuroscience Research:
In the field of neuroscience, (1-PHENYLETHYL)PYRIDIN-2-YLMETHYL-AMINE may be utilized for studying the mechanisms of action and potential therapeutic effects on the central nervous system. Its unique structure allows researchers to investigate its interactions with neurotransmitter systems and other biological targets, contributing to a better understanding of neurological processes and the development of novel treatments.
Used in Pharmacology:
(1-PHENYLETHYL)PYRIDIN-2-YLMETHYL-AMINE may also find applications in pharmacology, where it can be employed to study drug interactions, receptor binding, and other pharmacological properties. Its presence in drug formulations can provide insights into the development of new drugs with improved efficacy and safety profiles for the treatment of central nervous system disorders.

Upstream product

• 57707-75-2 2-pyridinal-1-phenylethylimine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 618-36-0 rac-methylbenzylamine 
• 38010-70-7 (S)-1-phenyl-N-[(pyridin-2-yl)methylene]ethanamine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 1215021-07-0 1[(S)-α-(methylbenzylamino)]-1-(R)-(2-pyridyl)-methyl-H-phosphinic acid 
• 125875-26-5 N-(2-pyridylmethylene)-(R)-1-phenylethylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 890415-63-1 (R)-(+)-1-[N-(α-methylbenzylamino)]-1-(2-pyridyl)-(S)-methyldiphenylphosphine oxide 
• 95341-88-1 (S)-1-phenyl-N-((E)-pyridin-2-ylmethylene)ethanamine 

Downstream Products

• 1612791-84-0 C₁₄H₁₆Cl₂N₂Pd 
• 1046826-67-8 [RuCl(CH₃C₆H₄CH(CH₃)2)(C₆H₅CH(CH₃)NHCH₂C₅H₄N)]⁽¹⁺⁾*SbF₆^(1-)=[RuCl(CH₃C₆H₄CH(CH₃)2)(C₆H₅CH(CH₃)NHCH₂C₅H₄N)]SbF₆ 

Relevant academic research and scientific papers

Synthesis and structures of copper(II) complexes containing N,N-bidentate N-substituted phenylethanamine derivatives as pre-catalysts for heterotactic-enriched polylactide

A series of Cu(II) complexes, [LnCuCl2]2 (Ln = (S)-N-((1H-pyrazol-1-yl)methyl)-1-phenylethanamine (L1), (S)-N-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-1-phenylethanamine (L2) and (S)-1-phenyl

Deciphering preferred geometries of pyridylmethylamines-based complexes: A robust strategy combining NMR, DFT and X-ray

The preparation of pyridylmethylamines (pma)-ZnBr2 and -CoBr2 complexes is described. Accurate structural informations in both solution and solid state have been obtained using an approach combining advanced NMR such as pure shift gr

Synthesis and characterization of aminopyridine iron(ii) chloride catalysts for isoprene polymerization: Sterically controlled monomer enchainment

In this study, a series of 2-R-6-(1-(alkylamino)methyl)pyridine-iron complexes [alkyl: (CPh3) Fe1H; (CHPh2) Fe2H; (CHPh2) Fe3Me; (CHMePh) Fe4H; (CH2Ph) Fe5H; (CHMe2) Fe6H; (C6H11) Fe7H; (CH2(4-OMe)Ph) Fe8H; (CH2(4-CF3)Ph) Fe9H; (CH2(2,4,6-Me3)Ph) Fe10H; (CH2Ph) Fe11Me] were synthesized and well characterized by ATR-IR spectroscopy, HRMS spectroscopy and elemental analysis. In addition, Fe3Me, Fe4H, Fe7H and Fe11Me were characterized by X-ray diffraction analysis: Fe3Me and Fe11Me adopted distorted tetrahedral geometries in the solid state while Fe4H and Fe7H were found in dimeric or polymeric forms respectively in which chlorides acted as bridging ligands. The catalytic capacities of these iron complexes were investigated for isoprene polymerization. Upon activation with a MAO cocatalyst, the catalytic activities of complexes varied as a function of the steric and electronic influences of substituents. In general, the catalysts bearing the least steric groups and electron-withdrawing groups exhibited relatively high activities. An outstanding activity of 190.6 × 104 g·mol-1·h-1 was obtained by Fe5H [CH2Ph]. Moreover, changes in the steric hindrance around the metal center showed a notable effect on the selectivity of monomer enchainment. In particular, most of the polymers obtained by these complexes bearing flexible frameworks were in favor of 3,4-enchainment.

Chiral Lithium Amido Zincates for Enantioselective 1,2-Additions: Auto-assembling Reagents Involving a Fully Recyclable Ligand

A methodology consisting in carrying out enantioselective nucleophilic 1,2-additions (ee values up to 97 %) from cheap, easily accessible, and never described before, chiral lithium amido zincates is presented. These multicomponent reactants auto-assemble when mixing, in a 1:1 ratio, a homoleptic diorganozinc (R2Zn) with a chiral lithium amide (CLA). The latter, obtained after a single reductive amination, plays the role of the chiral inductor and is fully recoverable thanks to a simple acid–base wash, allowing being recycled and re-use without loss of stereochemical information.

New potentially dhelating chiral magnesium amide bases for use in enantioselective deprotonation reactions

A series of chiral secondary amines, incorporating a five- or six-membered heterocycle, were synthesised and used to prepare novel chiral magnesium bisamide reagents. These amide bases were subsequently applied within asymmetric deprotonation reactions to

Compositions for reductive aminations utilizing supported tricarboxyborohydride reagents and methods of using the same

A modified solid-support for use as a supported reagent for use in reduction reactions, including reductive amination comprising a solid-support having an tetrasubstituted ammonium cation species ionically bonded to a borohydride anion species extending therefrom having the general formula: wherein P is a solid-support, S is a spacer group selected from the group consisting of alkylene, {including —(CH2)n—}, alkyleneoxy {including -0(CH2)n—}, alkylenethio {including —S(CH2)n—} and alkylenecarboxy, {including —O(O)C—(CH2)n—}, n=2-16. R1, R2, R3 and R are each independently selected from the group consisting of alkyl, cycloalkyl, haloalkyl and aryl. Y equals 1, 2 or 3. H is hydrogen or deuterium.

N-heterocyclic pyridylmethylamines: Synthesis, complexation, molecular structure, and application to asymmetric Suzuki-Miyaura and oxidative coupling reactions

The synthesis of N,N-bidentate ligands based on a π-deficient N-heterocyclic pyridylmethylamine core is described. The preparation and characterization of the corresponding N,N-ligand-palladium complexes in solution and the solid state are illustrated. Pd complexes showed a good yield and moderate catalytic activity (up to 40% ee) in the asymmetric Suzuki-Miyaura coupling reaction, leading to methoxybinaphthyl derivatives. The combination of N,N-pyridylmethylamines with cuprous iodide revealed effective catalytic systems in oxidative naphthol derivative coupling reactions, affording the corresponding binaphthyls in high yields and with enantioselectivities of up to 61%.

Enantioselective Friedel-Crafts alkylation of indole derivatives catalyzed by new Yb(OTf)3-pyridylalkylamine complexes as chiral Lewis acids

New Yb(OTf)3-pyridylalkylamine complexes have been employed as chiral Lewis acids in the enantioselective Friedel-Crafts alkylation of indole derivatives with trifluoropyruvates. The influence of the substituents as well as the configuration of

Grignard allylic substitution catalyzed by imidazol-2-ylidene- and imidazol-4-ylidene-magnesium complexes

In the presence of a catalytic amount of 1,2-disubstituted or 1,2,3-trisubstituted imidazolium salts, γ-substituted allyl chlorides reacted with alkyl Grignard reagents to undergo substitution reactions in an SN2′-selective fashion, where the magnesium ate complexes [(N-heterocyclic carbene-MgR3)-(MgX)+] of imidazol-2-ylidenes or imidazol-4-ylidenes, generated in situ, were postulated as the active species. It was observed that the reactions with imidazol-4-ylidene catalysts were faster than those with imidazol-2-ylidenes. Enantioselective catalysis using a chiral imidazolium salt was preliminarily investigated.

Aminophosphinic acids in a pyridine series, Part 2: Synthesis of 2-, 3-, and 4-pyridyl derivatives of 1-(Benzylamino)-methyl-H-phosphinic Acids

New 2-pyridyl, 3-pyridyl, and 4-pyridyl derivatives of 1-[N-(benzyl)amino]- methyl-H-phosphinic acid were prepared by the addition of bis(trimethylsilyl) phosphonite to the corresponding imines and subsequent methanolysis of the addition products. Treatment of the 2-pyridyl- and 1-(4-pyridyl)-1-(benzylamino) -methyl-H-phosphinic acids with aqueous mineral acids leads to cleavage and formation of the corresponding secondary amines and phosphorous acid (H3PO3).