202215-77-8

Basic information

• Product Name: (1R,3R)-(N-benzyl-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate
• Synonyms: (1R,3R)-(N-benzyl-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate
• CAS NO: 202215-77-8
• Molecular Weight: 646.621
• Mol File: 202215-77-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3R)-(N-benzyl-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R)-(N-benzyl-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate(202215-77-8)
• EPA Substance Registry System: (1R,3R)-(N-benzyl-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate(202215-77-8)

Safety Data

• Hazardous Substances Data: 202215-77-8(Hazardous Substances Data)

Upstream product

• 218956-26-4 (1R,3R)-N-benzyl-6-hydroxy-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 
• 765253-06-3 (1R,3R)-N-benzyl-6-methoxy-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 
• 202215-69-8 1-bromo-5-isopropoxy-4-methoxy-2-naphthoic acid 
• 202215-66-5 1-bromo-2-hydroxymethyl-5-isopropoxy-4-methoxynaphthalene 
• 202215-64-3 2-hydroxymethyl-5-isopropoxy-4-methoxynaphthalene 
• 202215-67-6 1-bromo-5-isopropoxy-4-methoxynaphthalene-2-carbaldehyde 
• 162147-18-4 Ethyl 8-bromo-5-isopropoxy-4-methoxy-2-naphthoate 

Downstream Products

• 146471-75-2 dioncophylline C 

Relevant articles and documents

First synthesis of the antimalarial naphthylisoquinoline alkaloid dioncophylline C, and its unnatural anti-HIV dimer, jozimine C1

The first total synthesis of dioncophylline C, a new antimalarial lead structure, is described. For the directed construction of the stereogenic biaryl axis, the 'lactone methodology' is applied, despite the lack of a 'bridgehead oxygen' function in the t