202260-01-3

Upstream product

• 202260-05-7 1-[3-S-(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)-3-thio-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]pyrimidine-2,4(1H,3H)-dione 
• 202259-89-0 Benzoic acid 2-((2R,3R,3aR,9aR)-6-oxo-2-trityloxymethyl-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ylsulfanyl)-ethyl ester 
• 202259-88-9 1-[(2R,3R,4S,5R)-3-Hydroxy-4-(2-hydroxy-ethylsulfanyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 96253-10-0 1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione 
• 1000029-49-1 1-{3-deoxy-3-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-arabinofuranosyl}pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 202260-03-5 1-{(2R,3S,4R,5R)-3-Benzylamino-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethanesulfonyl]-5-trityloxymethyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis, structure, and conformation of 2′,3′-fused oxathiane and thiomorpholine uridines

The syntheses of two 2′,3′-fused bicyclic nucleoside analogues, i.e., 1-[4aR,5R,7R,7aS)-hexahydro-S-(hydroxymethyl)-4,4-dioxidofuro[3,4-b][1,4] oxathiin-7-yl]pyrimidine-2,4(1H,3H)-dione (1a) and 1-[(4aS,5R,7R,7aS)-hexahydro- 7-(hydroxymethyl)-1,1-dioxido-

Sugar-Modified Uridine Bisvinyl Sulfone: Synthesis of a Bifunctionalized Nucleoside Michael Acceptor and Its Use in Stereoselective Tandem Cyclization

A bisvinyl sulfone functionality is incorporated into the carbohydrate moiety of uridine to synthesize 6 (or 7) which is a bifunctionalized nucleoside Michael acceptor and has the potential to form covalent bond with biological nucleophiles. This compound could be used to generate a large number and a new class of bicyclic S,S-dioxidethiazine derivatives 8-12 in stereoselective fashion. Compound 6 is also useful for the synthesis of a wide variety of monosubstituted compounds 13-15. The structures of compounds 8-12 have been established unambiguously by synthesising the core structure 28 in a stereospecific fashion.